Partial Block by Riluzole of Muscle Sodium Channels in Myotubes from Amyotrophic Lateral Sclerosis Patients

Table 1

Patients characteristics.

Patient (sex)	Age; (years)	Disease; duration (months)	Clinical; onset	+Riluzole			−Riluzole
					MRC right lower limb	CMAP peroneal nerve (mV)		MRC right lower limb	CMAP peroneal nerve (mV)
1 (M)	55	34	Spinal	81.3 (88, 80, 76)	19	2.6	24.7 (28, 30, 16)	20	2.5
2 (F)	53	24	Spinal	94.7 (100, 90, 94)	21	2.8	146.7 (145, 140, 155)	20	2.9
3 (F)	53	23	Spinal	133.3 (148, 140, 112)	21	3.1	73.3 (70, 70, 80)	21	3.0
4 (M)	71	36	Spinal	126.6 (115, 127, 138)	12	0.10	153.3 (158, 140, 162)	12	0.14
5 (M)	56	55	Spinal	60 (85, 56, 39)	18	1.8	48.3 (43, 35, 67)	18	1.7
6 (F)	61	30	Spinal	106.7 (105, 102, 113)	25	3.8	124.7 (118, 128, 128)	25	3.9
7 (F)	51	19	Spinal	63.3 (55, 47, 88)	26	4.0	48.3 (64, 49, 32)	26	4.2
8 (M)	58	16	Bulbar	27 (30, 25, 26)	31	9.7	32.3 (34, 38, 25)	31	9.8
9 (F)	75	27	Bulbar	32.7 (28, 37, 33)	27	9.8	36 (38, 32, 38)	27	9.6
10 (F)	63	10	Spinal	82 (78, 88, 80)	30	8.9	40 (45, 40, 35)	30	8.7
11 (M)	50	13	Spinal	106.7 (101, 100, 119)	29	7.7	33.3 (36, 35, 29)	29	7.6

Demographic and clinical characteristics of the 11 patients with ALS evaluated during riluzole treatment (+Riluzole) and after 1-week withdrawal (−Riluzole). : average number (number in each insertion) of fibrillation potentials (Fibs); MRC lower limbs: Medical Research Council score for lower limbs; CMAP: amplitude of peroneal compound muscle action potential. Number of Fibs is not significantly affected by riluzole treatment ( by Wilcoxon test).