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Neurology Research International
Volume 2014, Article ID 970793, 7 pages
Research Article

Aortic Stiffness Is Related to the Ischemic Brain Injury Biomarker N-Methyl-D-aspartate Receptor Antibody Levels in Aortic Valve Replacement

1Department of Surgery and Cancer, Imperial College London, 10th Floor, QEQM Wing, St Mary’s Campus, London W2 1NY, UK
2Departments of Cardiac Surgery and Cardiology, Imperial College Healthcare NHS Trust, London W12 0HS, UK
3International Centre for Circulatory Health, Imperial College Healthcare NHS Trust, London W2 1LA, UK

Received 24 March 2014; Accepted 15 June 2014; Published 26 June 2014

Academic Editor: Dirk Deleu

Copyright © 2014 Emaddin Kidher et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Aortic stiffness changes the flow pattern of circulating blood causing microvascular damage to different end-organ tissues, such as brain cells. The relationship between aortic stiffness measured by pulse wave velocity (PWV) and serum ischemic brain injury biomarker N-methyl-D-aspartate receptor antibody (NR2Ab) levels in aortic valve replacement has not been assessed. Methods. Patients undergoing aortic valve replacement (AVR) for aortic stenosis (AS) had their PWV and NR2Ab serum levels measured preoperatively. We analyzed PWV and NR2Ab in two ways: (1) as continuous variables using the actual value and (2) as dichotomous variables (PWV-norm and PWV-high groups) and (NR2Ab-low and NR2Ab-high groups). Results. Fifty-six patients ( years) were included in this study. The NR2Ab level (ng/mL) was significantly higher in the PWV-high group ( ) than in PWV-norm group ( ; median versus , resp., ). NR2Ab level was positively associated with PWV and negatively associated with male gender. Multiple regression revealed PWV independently related to NR2Ab level, and PWV cut-off was associated with a 7.23 times increase in the likelihood of having high NR2Ab (>1.8 ng/mL). Conclusion. Higher PWV in patients with surgical aortic stenosis is associated with higher levels of the ischemic brain biomarker NR2Ab.