Research Article

Aortic Stiffness Is Related to the Ischemic Brain Injury Biomarker N-Methyl-D-aspartate Receptor Antibody Levels in Aortic Valve Replacement

Table 2

Simple and multiple linear regression analysis to identify variables that independently predict NR2Ab level.

PredictorsNR2Ab level beta ( value)

Simple linear regression
PWV value0.27 (0.05)
PWV cut-off0.39 (<0.01)
Age−0.05 (0.71)
Gender (male)0.27 (0.05)
DM0.08 (0.57)
Smoking−0.12 (0.38)
BMI (kg/m2)−0.2 (0.15)
MAP (mmHg)−0.16 (0.26)
Cholesterol (mmol/L)0.09 (0.67)
EuroSCORE (logistic)0.07 (0.49)
AVA (cm2)−0.09 (0.55)
AVMG (mmHg)−0.01 (0.92)
AVPG (mmHg)−0.06 (0.66)
EF0.03 (0.83)

Multiple linear regression (Model 1)
PWV value0.37 (0.02)
Age−0.25 (0.12)
Gender (male)−0.21 (0.12)

Multiple linear regression (Model 2)
PWV cut-off0.37 (<0.01)
Age−0.09 (0.46)
Gender (male)−0.21 (0.11)

Values are shown as standardized beta coefficient ( value); bold values indicate statistical significance. Abbreviations: AVA, aortic valve area; AVMG, aortic valve mean gradient; AVPG, aortic valve peak gradient; BMI, body mass index; DM, diabetes mellitus; EF, Ejection fraction; MAP, mean arterial blood pressure; NR2Ab, N-methyl-D-aspartate (NMDA) receptor antibodies; PWV, pulse wave velocity.