Table of Contents Author Guidelines Submit a Manuscript
Neurology Research International
Volume 2015, Article ID 659189, 4 pages
http://dx.doi.org/10.1155/2015/659189
Research Article

Prevalence of Provocative Seizures in Persons with Epilepsy: A Longitudinal Study at Khon Kaen University Hospital, Thailand

1Division of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand
2Integrated Epilepsy Research Group, Khon Kaen University, Khon Kaen 40002, Thailand
3Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
4Research Center in Back, Neck, Other Joint Pain and Human Performance (BNOJPH), Khon Kaen University, Khon Kaen 40002, Thailand

Received 1 July 2015; Revised 15 September 2015; Accepted 28 September 2015

Academic Editor: Di Lazzaro Vincenzo

Copyright © 2015 Nutthaya Vongkasamchai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background and Objective. Provocative factors are one causative factor of seizure attacks in persons with epilepsy (PWE). There are limited data of prevalence and major provocative factors in Asian populations. Methods. This study was performed at the Epilepsy Clinic, Khon Kaen University Hospital. The patients who aged 15 years or over, who had been treated at least 3 months with at least one antiepileptic drug, and who were followed up for at least one year were included. Data of seizure control and triggers were collected retrospectively from medical records. Data analysis was performed to identify independent provocative factors. Results. A total of 382 PWE met the study criteria. The mean age was years. Approximately 44% of the patients had at least one provocative factor. By multivariate analysis, the independent provocative factors with the first three highest adjusted odds ratios were sleep deprivation (adjusted , 95% CI 3.73–19.99), alcohol consumption (adjusted , 95% CI 1.44–31.78), and feeling stressful (adjusted , 95% CI 1.29–6.86). Conclusion. Almost half of seizure attacks may be caused by provocative factors in Thai PWEs and some factors may be preventable. Avoidance of these factors should be emphasized to epilepsy patients for improving clinical outcomes and quality of life.