Comparing the Expression of Genes Related to Serotonin (5-HT) in C57BL/6J Mice and Humans Based on Data Available at the Allen Mouse Brain Atlas and Allen Human Brain Atlas

Table 1

List of genes to various serotonin-related processes considered in this study.

Process	Genes	Gene ID	Name	Function	References
Neurodevelopment	PET-1	260298	FEV (ETS oncogene family)	Development of serotonin neurons	[12, 27–30]
Enzymatic synthesis	TPH-1	21990	Tryptophan hydroxylase	Converts tryptophan in 5-hydroxytriptophane	[12, 27, 31]
	TPH-2	121278	Tryptophan hydroxylase	Converts tryptophan in 5- hydroxytryptophan (exclusive for brain tissue)	[12, 27, 31–33]
	AADC; [nonspecific gen in 5-HT metabolism]	13195	aromatic enzyme decarboxylase	Converts 5-hydroxytryptófano into 5-HT and catalyzes different decarboxylation reactions with monoamines	[12, 27, 28]
Store	VMAT-1 [nonspecific gen in 5-HT metabolism]	110877	Monoamine vesicular transporter-1	Vesicular storing of 5-HT and transport other monoamine neurotransmitters	[12, 27, 28, 34]
	VMAT-2 [nonspecific gen in 5-HT metabolism]	25549	Monoamine vesicular transporter -2	Vesicular storing of 5-HT and transport other monoamine neurotransmitters	[12, 27, 28, 34]
	5HTT (Slc6a4)	15567	Serotonin transporter	5-HT reuptake	[12, 27, 28]
Receptor interaction	HTR1A	15550	Serotonin receptor 1A	5-HT Receptor coupled to a Gi-o protein (pre and postsynaptic)	[12, 27, 28, 35]
	HTR1B	15551	Serotonin receptor 1B	5-HT Receptor coupled to a Gi – protein (pre and postsynaptic)	[12, 27, 28, 35]
	HTR1D	15552	Serotonin receptor 1D	5-HT Receptor coupled to a Gi – protein (pre and postsynaptic)	[12, 27, 28, 35]
	HTR1F	15557	Serotonin receptor 1F	5-HT Receptor coupled to a Gi – protein	[12, 27, 28, 35]
	HTR2A	15558	Serotonin receptor 2A	5-HT Receptor coupled to a Gq	[12, 27, 28, 35]
	HTR2B	15559	Serotonin receptor 2B	5-HT Receptor coupled to a Gq	[12, 27, 28, 35]
	HTR2C	15560	Serotonin receptor 2C	5-HT Receptor coupled to a Gq	[12, 27, 28, 35]
	HTR3A	15561	Serotonin receptor 3A	Receptor coupled to an ion cannel	[12, 27, 28, 35]
	HTR3B	57014	Serotonin receptor 3B	Receptor coupled to an ion cannel	[12, 27, 28, 35]
	HTR4	15562	Serotonin receptor 4	5-HT Receptor coupled to a Gs	[12, 27, 28, 35]
	HTR5A	15563	Serotonin receptor 5A	Receptor coupled to a Gi and Go	[12, 27, 28]
	HTR5B	15564	Serotonin receptor 5B	Receptor coupled to a Gi and Go	[12, 27, 28, 35]
	HTR6	15565	Serotonin receptor 6	Receptor coupled to a GS	[12, 27, 28, 35]
	HTR7	15566	Serotonin receptor 7	Receptor coupled to a GS	[12, 27, 28, 35]
Degradation	MAOA [nonspecific in 5-HT metabolism]	17161	Monoamine oxidase-A	Inactivation of 5-HT and other monoamines	[12, 27, 28]
	MAOB [nonspecific in 5-HT metabolism]	109731	Monoamine oxidase-B	Inactivation of 5-HT and other monoamines	[12, 27, 28]