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Neurology Research International
Volume 2018 (2018), Article ID 8218697, 10 pages
Research Article

The Role of Moderate Aerobic Exercise as Determined by Cardiopulmonary Exercise Testing in ALS

1Translational and Clinical Physiology Unit, Molecular Medicine Institute, Faculty of Medicine, University of Lisbon, Lisbon, Portugal
2Department of Physical Medicine and Rehabilitation, Hospital Santa Maria-CHLN, Faculty of Medicine, University of Lisbon, Lisbon, Portugal
3Department of Neurosciences, Hospital Santa Maria-CHLN, Lisbon, Portugal

Correspondence should be addressed to Anna Caroline Marques Braga; moc.liamtoh@oreaenilorac

Received 12 July 2017; Accepted 5 September 2017; Published 31 January 2018

Academic Editor: Laura Brighina

Copyright © 2018 Anna Caroline Marques Braga et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. The efficacy of cardiopulmonary exercise testing (CPET) to determining exercise intensity has not been established in Amyotrophic Lateral Sclerosis (ALS). We studied this intervention. Methods. We included 48 ALS patients randomized in 2 groups: G1 (), exercise intensity leveled by CPET; G2 (), standard care limited by fatigue, during 6 months. ALS functional scale (ALSFRS-R) and forced vital capacity (FVC) were performed every 3 months; CPET was done at admission () and 6 months later (). We registered oxygen uptake, carbon dioxide output, and ventilation at anaerobic threshold and at peak effort. Primary outcome was functional change. We used parametric statistics for comparisons and multiple regression analyses to identify independent predictors of functional decline. Results. At both groups were identical, except for higher FVC in G1 (). At , ALSFRS-R was higher () in G1. Gas exchange variables at did not change in G1 but had significant differences in G2 (). Multiregression analyses showed the Spinal ALSFRS-R slope and Intervention group () as significant predictors of ALSFRS-R at . Conclusion. Aerobic exercise defined by CPET is feasible and can improve functional outcome in ALS. This trial is registered with Clinical ID: NCT03326622.