The Role of Moderate Aerobic Exercise as Determined by Cardiopulmonary Exercise Testing in ALS

Table 2

Clinical and demographic characteristics of the ALS patients at diagnosis (T0), admission to the study protocol (T1), and the end of study (T2). -Test: mean and standard deviation values for both groups.

	Group 1 ()	Group 2 ()	value
Male (%)	18 (75%)	14 (59%)	0.20
Spinal onset form (%)	21 (88%)	17 (70%)	0.12
Use of NIV T1-T2 (Yes – No)	14Y/10N	13Y/11N	0.75
Age at onset (years)	63.21 (±13.0)	62 (±12.06)	0.42
Disease duration (T0-T1) (months)	10.8 (±6.5)	10.79 (±7.7)	0.80
% FVC predicted (T1)	99.64 (±21.8)	80.0 (±21.0)	0.002
ALSFRS-R total score (T0)	42.92 (±3.51)	41.13 (±4.83)	0.14
ALSFRS-R total score (T1)	40.25 (±5.00)	37.25 (±4.9)
ALSFRS-R total score (T2)	34.1 (±7.1)	29.5 (±7.7)	0.035
ALSFRS-R Tot sc. slope (T1-T2)	1.01 (±0.92)	1.28 (±1.10)	0.36
ALSFRS-R bulbar slope (T1-T2)	0.15 (±0.24)	0.18 (±0.25)	0.62
ALSFRS-R spinal slope (T1-T2)	0.66 (±0.64)	0.75 (±0.97)	0.68
ALSFRS-R respiratory slope (T1-T2)	0.20 (±0.26)	0.30 (±0.32)	0.23

G1: controlled exercise Group, G2: standard care group, T0: at diagnosis; T1: at start of to study; T2: end of study; Sp: spinal onset, Bb: bulbar onset; use of NIVT1-T2: use of noninvasive ventilation during period of study; % FVC predicted T1: % forced vital capacity predicted at start of study (T1);: ALSFRS-R total at diagnosis moment; : ALSFRS-R total at end of study; slope : slope ALSFRS-R total between start and end of exercise protocol (T1-T2); significant results are represented in bold. ALSFRS-R total score on T1 (Subscores between G1 and G2 (NS): bulbar score: ; spinal score: ; Respiratory score: ).