Myelin Basic Protein and Cardiac Sympathetic Neurodegeneration in Nonhuman Primates
Cardiac MBP-immunoreactive (-ir) spot number in normal rhesus macaques follows a base to apex gradient. Bar graph (a) of the total number of MBP-ir spots (median ± interquartile range) counted in each anatomical area (3 levels ∗ 4 regions) in the normal, control animals. Bar graph (b) of the estimated percentage of bundles with any MBP-ir spots (mean ± standard error of the mean) in each anatomical area in control animals. Bar graphs of the average (mean ± standard error of the mean) percentage of fibers myelinated in bundles (c), the number of nerve bundles (d), or size of nerve bundles (e) in the base and apex levels of control animals; each point represents one myocardial nerve bundle. , septal region, inferior region; see Supplementary Figure S4 for more details. Note that (d) and (e) include data from all regions in the base and apex levels, while (c) includes only the anterior region. MBP, myelin basic protein; S, septal; A, anterior; L, lateral; I, inferior.
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