Evaluation of Retinal Structure and Optic Nerve Function Changes in Multiple Sclerosis: Longitudinal Study with 1-Year Follow-Up

Table 4

Comparison of baseline, 6 months, and 12 months of evaluation on GCIPL and RNFL thickness of MS eyes.

Variable	MS
	n	Baseline	n	6 months	n	12 months	0 vs 6	6 vs 12	0 vs 12
Mean ± standard deviation
GCIPL
Mean	54	70.89 ± 10.60	34	69.38 ± 10.87	20	67.95 ± 11.12	0.105^a	0.150^a	0.007^a
Superior	54	71.11 ± 11.44	34	70.32 ± 11.07	20	68.82 ± 11.59	1.000^b	0.579^b	0.619^b
Superonasal	54	71.00 ± 12.51	34	69.88 ± 12.65	20	68.05 ± 12.90	0.294^a	0.038^a	0.053^a
Inferonasal	54	70.28 ± 12.74	34	68.65 ± 12.65	20	67.41 ± 13.75	0.039^a	0.495^a	0.012^a
Inferior	54	69.35 ± 11.06	34	68.18 ± 11.02	20	66.45 ± 11.68	0.394^a	0.208^a	0.046^a
Inferotemporal	54	71.83 ± 10.12	34	70.06 ± 10.46	20	68.36 ± 10.49	0.108^a	0.284^a	0.012^a
Superotemporal	54	71.15 ± 9.82	34	69.15 ± 10.25	20	69.00 ± 10.37	0.080^b	1.000^b	0.389^b
RNFL
Mean	54	88.48 ± 14.08	34	87.62 ± 14.12	20	86.50 ± 14.22	1.000^b	1.000^b	0.836^b
Superior	54	115.69 ± 21.95	34	115.91 ± 25.69	20	114.50 ± 22.71	1.000^b	1.000^b	1.000^b
Nasal	54	68.17 ± 10.60	34	67.79 ± 9.66	20	68.50 ± 8.77	0.933^a	0.093^a	0.004^a
Inferior	54	110.28 ± 20.78	34	107.62 ± 22.09	20	105.45 ± 22.25	1.000^a	0.368^a	0.727^a
Temporal	54	59.37 ± 16.82	34	59.32 ± 15.61	20	57.85 ± 17.41	0.376^b	0.537^b	1.000^b
Gambaran fundus; N (%)
Normal	31 (57.4)	—	14 (41.2)	—	8 (36.4)	—	0.138^c	0.719^c	0.096^c
Atrofi papil	23 (42.6)	—	20 (58.8)	—	14 (63.6)	—

GCIPL: ganglion cell inner plexiform layer; RNFL: retinal nerve fiber layer, ^aFriedman test followed by Wilcoxon test, ^bRepeated ANOVA followed by Bonferonni test, ^cChi-square test.