Neurology Research International

Amyotrophic Lateral Sclerosis and Novel Therapeutic Strategies


Publishing date
24 Aug 2012
Status
Published
Submission deadline
06 Apr 2012

Lead Editor

1Neurobiology and developmental Sciences, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA

2Department of Neurology, Hannover Medical School, Hanover, Germany

3Department of Neurology, Johns Hopkins University, Baltimore, MD, USA

4Department of Pathology and Neuroscience, Toledo University, Toledo, OH, USA

5Department of Neurology, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA


Amyotrophic Lateral Sclerosis and Novel Therapeutic Strategies

Description

Amyotrophic lateral sclerosis (ALS) or motor neuron disease is a progressive, lethal, neurodegenerative disorder of motor neurons. The pathologic hallmark of this disease is the selective death of motor neurons in the brain and spinal cord, leading to paralysis of voluntary muscles. Studies on the disease-causing genes in cellular and animal models of ALS have led to a better understanding of the pathogenic mechanisms of motor neuron degeneration. Putative mechanisms include protein misfolding and aggregation, proteasome impairment, neuroinflammation, reactive oxygen species, excitotoxicity, and mitochondrial dysfunction. Transgenic mouse models of ALS and, more recently, induced pluripotent stem cells (iPS) provide an invaluable tool to test these putative mechanisms and novel therapeutics. Currently, there is only one approved treatment for ALS, and it is only modestly effective; therefore, there is a critical need for novel therapeutics to treat this devastating disease. We are interested in papers with relevance to the pathogenesis of ALS, with a particular focus on mechanisms related to genetic abnormalities in SOD1, TDP-43, FUS/LTS, and Valosin-containing protein (VCP/97). Papers addressing and critically evaluating recent preclinical and clinical trials in ALS would have priority. Potential topics include, but are not limited to:

  • Genetic discoveries in ALS
  • Newly developed models for ALS (rodents, nonrodents)
  • Mechanism of motor neuron degeneration
  • Role of inflammation in ALS
  • Contribution of glial cells to motor neuron death in ALS
  • Autophagy and ALS
  • Biomarkers for early diagnosis and clinical evaluation in ALS
  • iPS cells and ALS
  • ALS and FTD: distinct diseases or coincidental overlap
  • Experimental therapies in ALS
  • Current and future clinical trials in ALS patients

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/nri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 798028
  • - Editorial

Amyotrophic Lateral Sclerosis and Novel Therapeutic Strategies

Brett Morrison | Kenneth Hensley | ... | Mahmoud Kiaei
  • Special Issue
  • - Volume 2012
  • - Article ID 853030
  • - Erratum

Erratum to “Progress in Therapy Development for Amyotrophic Lateral Sclerosis”

Kalina Venkova-Hristova | Alexandar Christov | ... | Kenneth Hensley
  • Special Issue
  • - Volume 2012
  • - Article ID 878030
  • - Review Article

Nrf2/ARE Signaling Pathway: Key Mediator in Oxidative Stress and Potential Therapeutic Target in ALS

Susanne Petri | Sonja Körner | Mahmoud Kiaei
  • Special Issue
  • - Volume 2012
  • - Article ID 625245
  • - Review Article

D-Serine Production, Degradation, and Transport in ALS: Critical Role of Methodology

John P. Crow | John C. Marecki | Misty Thompson
  • Special Issue
  • - Volume 2012
  • - Article ID 379657
  • - Review Article

Neuromuscular Junction Protection for the Potential Treatment of Amyotrophic Lateral Sclerosis

Dan Krakora | Corey Macrander | Masatoshi Suzuki
  • Special Issue
  • - Volume 2012
  • - Article ID 806306
  • - Review Article

ALS and Frontotemporal Dysfunction: A Review

Eugene Y. Achi | Stacy A. Rudnicki
  • Special Issue
  • - Volume 2012
  • - Article ID 608501
  • - Review Article

Magnetic Resonance Imaging in Amyotrophic Lateral Sclerosis

Katja Kollewe | Sonja Körner | ... | Bahram Mohammadi
  • Special Issue
  • - Volume 2012
  • - Article ID 187234
  • - Review Article

Progress in Therapy Development for Amyotrophic Lateral Sclerosis

Kalina Venkova-Hristova | Alexandar Christov | ... | Kenneth Hensley
  • Special Issue
  • - Volume 2012
  • - Article ID 582075
  • - Clinical Study

A Pilot Trial of Pioglitazone HCl and Tretinoin in ALS: Cerebrospinal Fluid Biomarkers to Monitor Drug Efficacy and Predict Rate of Disease Progression

Todd D. Levine | Robert Bowser | ... | Kendall Van Keuren-Jensen
  • Special Issue
  • - Volume 2012
  • - Article ID 803701
  • - Review Article

The Neuroinflammatory Response in ALS: The Roles of Microglia and T Cells

Coral-Ann Lewis | John Manning | ... | Charles Krieger
Neurology Research International
 Journal metrics
Acceptance rate18%
Submission to final decision68 days
Acceptance to publication73 days
CiteScore1.280
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