TY - JOUR A2 - Dorsey, Susan AU - Graves, Brian T. AU - Munro, Cindy L. PY - 2013 DA - 2013/07/09 TI - Epigenetics in Critical Illness: A New Frontier SP - 503686 VL - 2013 AB - Epigenetics is the study of alterations in the function of genes that do not involve changes in the DNA sequence. Within the critical care literature, it is a relatively new and exciting avenue of research in describing pathology, clinical course, and developing targeted therapies to improve outcomes. In this paper, we highlight current research relative to critical care that is focused within the major epigenetic mechanisms of DNA methylation, histone modification, microRNA regulation, and composite epigenetic scoring. Within this emerging body of research it is quite clear that the novel therapies of the future will require clinicians to understand and navigate an even more complex and multivariate relationship between genetic, epigenetic, and biochemical mechanisms in conjunction with clinical presentation and course in order to significantly improve outcomes within the acute and critically ill population. SN - 2090-1429 UR - https://doi.org/10.1155/2013/503686 DO - 10.1155/2013/503686 JF - Nursing Research and Practice PB - Hindawi Publishing Corporation KW - ER -