The Association between KIF6 Single Nucleotide Polymorphism rs20455 and Serum Lipids in Filipino-American Women

Table 3

Selective cardiovascular disease risk factors as a function of the rs20455 genotype and statin medication usage.

Risk factors	AA; Trp/Trp; 𝑛=53; 23%	AG; Arg/Trp; 𝑛=120; 51%	GG; Arg/Arg; 𝑛=62; 26%	ANOVA; 𝑃 value
Age
Total	52±7	54±7	52±6.9	0.09
No statins	51±10	52±9	50±10	0.28
Statins	52±4	54±6	52±7
HDL-C
Total	60±14	64±15	61±16	0.21
No statins	60±16	65±7	63±15	0.06
Statins	56±11	61±15	52±14
LDL-C
Total	114±36	113±38	113±37	0.71
No statins	118±39	119±39	116±34	0.59
Statins	106±32	101±36	113±40
TG
Total	119±58	109±67	130±74^1,2	0.009
No statins	118±60	107±74	111±54
Statins	121±50	113±39	177±97^3	0.002
Waist Circ
Total	37±7	37±6	36±7
No statins	36±6	37±4	37±4	0.93
Statins	37±4	36±7	37±3
BMI
Total	26±4	28±4	26±4	0.06
No statins	26±4	27±4	25±5
Statins	30±5	30±4	27±5	0.15
Hs-CRP
Total	1.41±1.5	1.86±2.2	1.55±2.1	0.45
No statins	2.1±3.9	2.2±3.3	1.6±1.7
Statins	1.6±2.9	1.4±1.9	2.2±3.0	0.87
HbA1c
Total	5.8±0.46	5.8±0.49	6.01±0.97	0.39
No statins	5.8±0.48	5.8±0.48	5.9±0.66
Statins	6.3±1.2	6.1±0.54	6.4±1.5	0.17

Note: HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein-cholesterol; TG: triglycerides; Waist Circ: waist circumference; BMI: body mass index; hs-CRP: high-sensitivity C-reactive protein; HbA1c: Hemoglobin A1c. ¹𝑃<0.05 Trp/Trp versus Arg/Arg, ²𝑃<0.01 Arg/Trp versus Arg/Arg, and ³Arg/Arg versus all other groups 𝑃<0.001; AA no statins 𝑛=22, statins 𝑛=12; AG no statins 𝑛=48, statins 𝑛=21; GG no statins 𝑛=26, statins 𝑛=16.