Table of Contents
Research Letters in Organic Chemistry
Volume 2008, Article ID 209830, 4 pages
http://dx.doi.org/10.1155/2008/209830
Research Letter

Synthesis and Biological Evaluation of 7-O-Modified Formononetin Derivatives

School of Life Sciences, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, China

Received 15 July 2008; Accepted 27 September 2008

Academic Editor: Alexander Greer

Copyright © 2008 Ying Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. V. M. Malikov and M. P. Yuldashev, “Phenolic compounds of plants of the Scutellaria genus. Distribution, structure, and properties,” Chemistry of Natural Compounds, vol. 38, no. 5, pp. 473–519, 2002. View at Publisher · View at Google Scholar
  2. M. J. del Baño, J. Lorente, J. Castillo et al., “Flavonoid distribution during the development of leaves, flowers, stems, and roots of Rosmarinus officinalis. Postulation of a biosynthetic pathway,” Journal of Agricultural and Food Chemistry, vol. 52, no. 16, pp. 4987–4992, 2004. View at Publisher · View at Google Scholar
  3. P. L. Whitten, S. Kudo, and K. K. Okubo, “Isoflavonoids,” in Handbook of Plant and Fungal Toxicants, pp. 117–137, CRC Press, Boca Raton, Fla, USA, 1997. View at Google Scholar
  4. G. M. Boland and D. M. X. Donnelly, “Isoflavonoids and related compounds,” Natural Product Reports, vol. 15, no. 3, pp. 241–260, 1998. View at Publisher · View at Google Scholar
  5. K. T. Papazisis, D. Zambouli, O. T. Kimoundri et al., “Protein tyrosine kinase inhibitor, genistein, enhances apoptosis and cell cycle arrest in K562 cells treated with ?-irradiation,” Cancer Letters, vol. 160, no. 1, pp. 107–113, 2000. View at Publisher · View at Google Scholar
  6. A. Ullrich and J. Schlessinger, “Signal transduction by receptors with tyrosine kinase activity,” Cell, vol. 61, no. 2, pp. 203–212, 1990. View at Publisher · View at Google Scholar
  7. S. R. Hubbard and J. H. Till, “Protein tyrosine kinase structure and function,” Annual Review of Biochemistry, vol. 69, pp. 373–398, 2000. View at Publisher · View at Google Scholar
  8. F. M. Uckun and C. Mao, “Tyrosine kinases as new molecular targets in treatment of inflammatory disorders and leukemia,” Current Pharmaceutical Design, vol. 10, no. 10, pp. 1083–1091, 2004. View at Publisher · View at Google Scholar
  9. P. Traxler, J. Green, H. Mett, U. Séquin, and P. Furet, “Use of a pharmacophore model for the design of EGFR tyrosine kinase inhibitors: isoflavones and 3-phenyl-4(1H)-quinolones,” Journal of Medicinal Chemistry, vol. 42, no. 6, pp. 1018–1026, 1999. View at Publisher · View at Google Scholar
  10. X. Yu, W. Wang, and M. Yang, “Antioxidant activities of compounds isolated from Dalbergia odorifera T. Chen and their inhibition effects on the decrease of glutathione level of rat lens induced by UV irradiation,” Food Chemistry, vol. 104, no. 2, pp. 715–720, 2007. View at Publisher · View at Google Scholar
  11. Y. Ungar, O. F. Osundahunsi, and E. Shimoni, “Thermal stability of genistein and daidzein and its effect on their antioxidant activity,” Journal of Agricultural and Food Chemistry, vol. 51, no. 15, pp. 4394–4399, 2003. View at Publisher · View at Google Scholar
  12. S. Sato, J. Takeo, C. Aoyama, and H. Kawahara, “Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens,” Bioorganic & Medicinal Chemistry, vol. 15, no. 10, pp. 3445–3449, 2007. View at Publisher · View at Google Scholar
  13. Z.-N. Ji, W. Y. Zhao, G. R. Liao et al., “In vitro estrogenic activity of formononetin by two bioassay systems,” Gynecological Endocrinology, vol. 22, no. 10, pp. 578–584, 2006. View at Publisher · View at Google Scholar
  14. S. Medjakovic and A. Jungbauer, “Red clover isoflavones biochanin A and formononetin are potent ligands of the human aryl hydrocarbon receptor,” The Journal of Steroid Biochemistry and Molecular Biology, vol. 108, no. 1-2, pp. 171–177, 2008. View at Publisher · View at Google Scholar
  15. L.-N. Zhang, Z.-P. Xiao, H. Ding et al., “Synthesis and cytotoxic evaluation of novel 7-O-modified genistein derivatives,” Chemistry & Biodiversity, vol. 4, no. 2, pp. 248–255, 2007. View at Publisher · View at Google Scholar
  16. J. Meletiadis, J. F. G. M. Meis, J. W. Mouton, J. P. Donnelly, and P. E. Verweij, “Comparison of NCCLS and 3-(4,5-dimethyl-2-thiazyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) methods of in vitro susceptibility testing of filamentous fungi and development of a new simplified method,” Journal of Clinical Microbiology, vol. 38, no. 8, pp. 2949–2954, 2000. View at Google Scholar
  17. M. Hajdúch, V. Mihál, J. Minarík et al., “Decreased in vitro chemosensitivity of tumour cells in patients suffering from malignant diseases with a poor prognosis,” Cytotechnology, vol. 19, no. 3, pp. 243–245, 1996. View at Publisher · View at Google Scholar
  18. National committee for clinical laboratory standards, “Reference methed for broth dilution antifungal susceptibility testing of yeasts: approved standard,” M27-A, NCCLS, Wayne, Pa, USA, 1997.
  19. National committee for clinical laboratory standards, “Development of in vitro susceptibility testing criteria and quality control parameters: tentative guideline,” M23-T3, NCCLS, Villanova, Pa, USA, 1998.