Table of Contents
Research Letters in Organic Chemistry
Volume 2008, Article ID 594826, 4 pages
Research Letter

Three-Component One-Pot Synthesis of Novel Benzo[ 𝑏 ]1,8-naphthyridines Catalyzed by Bismuth(III) Chloride

Department of PG Studies and Research in Industrial Chemistry, School of Chemical Sciences, Kuvempu University, Shankaraghatta, Karnataka 577451, India

Received 21 July 2008; Accepted 23 November 2008

Academic Editor: Pierre Esteves

Copyright © 2008 Tangali R. Ravikumar Naik et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A novel and efficient three-component one-pot synthesis of benzo[ 𝑏 ]1,8-naphthyridines by 2-amino-4-methylquinoline, aromatic aldehydes, and malononitrile was done. The reaction was catalyzed by an acidic Bismuth(III) chloride, functionalized Bismuth(III) chloride, at room temperature to give various benzo[ 𝑏 ]1,8-naphthyridines in high yields. The Bismuth(III) chloride is an environmentally friendly catalyst.