Table of Contents
Research Letters in Organic Chemistry
Volume 2009, Article ID 109717, 5 pages
http://dx.doi.org/10.1155/2009/109717
Research Letter

Solvent-Free Microwave Synthesis of Aryloxypropanolamines by Ring Opening of Aryloxy Epoxides

1Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (CSMCRI), Council of Scientific and Industrial Research (CSIR), G. B. Marg, Bhavnagar 364 002, Gujarat, India
2Leibniz-Institute for Surface Modification e.V. (IOM), Permoserstraße 15, 04318 Leipzig, Germany
3Analytical Science Division, Central Salt and Marine Chemicals Research Institute (CSMCRI), G. B. Marg, Bhavnagar 364 002, Gujarat, India

Received 18 December 2008; Accepted 26 January 2009

Academic Editor: Kazuaki Ishihara

Copyright © 2009 Rukhsana I. Kureshy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The ring opening reaction of aryloxyepoxides with isopropylamine under solvent-free microwave irradiation produced therapeutically useful 𝛽 -blockers-aryloxypropanolamines in excellent yield (up to 98%) in 10 minutes which is considerably less than the time taken in classical heating ( 1 6 hours).