Table of Contents
Research Letters in Organic Chemistry
Volume 2009, Article ID 240253, 5 pages
Research Letter

Accelerations in the Lactonization of Trimethyl Lock Systems Are due to Proximity Orientation and not to Strain Effects

Faculty of Pharmacy, Al-Quds University, P. O. Box 20002, Jerusalem, Occupied Palestinian Territory

Received 18 November 2008; Accepted 20 January 2009

Academic Editor: Robert Flowers

Copyright © 2009 Rafik Karaman. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


DFT at B3LYP/6-31G(d,p) and HF at 6-31G and AM1 semiempirical calculations of thermodynamc and kinetc parameters for the trimethyl lock system (an important enzyme model) indicate that the remarkable enhancement in the lactonizations is largely the result of a proximity orientation as opposed to the currently advanced strain effect.