Table of Contents
Organic Chemistry International
Volume 2010, Article ID 496818, 5 pages
Research Article

Superacid-Induced Reactions of Nefopam

Department of Chemistry and Biochemistry, Northern Illinois University, DeKalb, IL 60115, USA

Received 10 November 2009; Revised 13 February 2010; Accepted 16 March 2010

Academic Editor: Cyril Parkanyi

Copyright © 2010 Larecia Knoecer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The analgesic drug nefopam reacts in superacidic media to form a dicationic superelectrophiles by ring opening. The dication species is capable of reacting with arenes in Friedel-Crafts-type conversions. This chemistry is used to prepare novel derivatives of nefopam.