Table of Contents
Organic Chemistry International
Volume 2010 (2010), Article ID 603436, 11 pages
http://dx.doi.org/10.1155/2010/603436
Research Article

Study of Catalytic Hydrogenation and Methanol Addition to α-Methylene-γ-Lactone of Eremanthine Derivatives

Departamento de Química, Instituto de Ciências Exatas, Universidade Federal Rural do Rio de Janeiro, 23890-970 Seropédica RJ, Brazil

Received 29 September 2010; Accepted 4 November 2010

Academic Editor: Emmanuel Theodorakis

Copyright © 2010 José C. F. Alves. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The sesquiterpene lactones guaia-1(10),11(13)-dieno-4α-hydroxy,9α-acetyl-15-iodine-12,6α-lactone (2), guaia-1(10),4(15),11(13)-trieno-9α-hydroxy-12,6α-lactone (3), (11S)-guaia-4(15),10(14)-dieno-9α-hydroxy-13-methoxy-12,6α-lactone (4), (11S)-guai-1(10)-eno-4α,9α-dihydroxy-13-methoxy-12,6α-lactone (5), and guaia-1(10),11(13)-dieno-4α,9α-dihydroxy-15-iodine-12,6α-lactone (6) were previously obtained starting from the natural product eremanthine (1). In this paper we report the catalytic hydrogenation reactions of allylic derivatives 25 and the methanol addition to α-methylene-γ-lactone of the iodohydrin 6.