Study of Catalytic Hydrogenation and Methanol Addition to α-Methylene-γ-Lactone of Eremanthine Derivatives
Scheme 6
Reagents and conditions: (i) H2 (55 psi), 10% Pd-C (0.1 equiv), EtOH (r. t., 30 min); (ii) 4 mol L−1 NaOH (5.5 equiv), DMF (reflux, 2.5 h). The experimental procedures for the sequence of reactions described in this scheme are similar to the ones previously described in [1], using only the isomer 5 as starting material. Substance previously described in [1].
