Table of Contents
Organic Chemistry International
Volume 2011, Article ID 753142, 4 pages
Research Article

Melamine Nitrate: A Novel and Efficient Reagent for Regioselective Nitration of Phenols

Department of Chemistry, College of Science, Huazhong Agricultural University, Wuhan, Hubei 430070, China

Received 2 April 2011; Accepted 5 May 2011

Academic Editor: Feihe Huang

Copyright © 2011 Yong-qiang Chen and Hong Jiang. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Melamine nitrate (MN) as a novel nitration reagent was easily prepared. Regioselective nitration of phenols to their corresponding o-nitrophenols occurred using MN with p-toluenesulfonic acid as catalyst in good to excellent yields. A distinct advantage of this method is the easy separation of products by simple filtration.