Table of Contents
Organic Chemistry International
Volume 2012, Article ID 289023, 7 pages
Research Article

Transition Metal Ions as Efficient Catalysts for Facile Ortho-Formylation of Phenols under Vilsmeier–Haack Conditions

1Department of Chemistry, Muffakham Jah College of Engineering and Technology, Mount Pleasant, Banjara Hills, Hyderabad 500034, India
2Department of Chemistry, Osmania University, Hyderabad 500007, India
3National Institute of Pharmaceutical Education and Research (NIPER) Balanagar, Hyderabad 500037, India

Received 31 August 2012; Revised 16 October 2012; Accepted 20 October 2012

Academic Editor: Paul Watts

Copyright © 2012 F. Aneesa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aromatic compounds (phenols), when treated with Vilsmeier Haack (V-H) reagent in the presence of transition metal ions such as Cu(II), Ni(II), Co(II), Cd(II), and Zn(II) under reflux conditions, afforded corresponding ortho-formyl derivatives in good yields. Under normal conditions the metal-ion-free V-H reactions are too sluggish and resulted in poor yields. This protocol provides highly regioselective formylation under a mild and efficient condition with simple workup.