Table of Contents
Organic Chemistry International
Volume 2012, Article ID 293945, 5 pages
Research Article

Preparation and Structure of Novel Chiral 4,6-Disubstituted Tetrahydropyrimidinones

School of Chemistry, National University of Ireland, University Road, Galway, Ireland

Received 9 July 2012; Accepted 11 October 2012

Academic Editor: Ken Shimizu

Copyright © 2012 David Frain et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The synthesis of a number of novel 4,6-disubstituted tetrahydropyrimidinones is described. The synthetic route described is applied to the synthesis of two stereoisomers. The structure of one tetrahydropyrimidinone was determined by XRD and showed an interesting hydrogen-bonded ribbon in the direction of crystal growth. These pyrimidinones are members of a class of compounds with diverse bioactivity. An initial study of their activity versus HIV protease is included.