Research Article

Environmentally Benign Mortar-Pestle-Induced Acylation and O-Alkylation of Aromatic and Heteroaromatic Compounds under Solvent-Free Micellar Conditions and Computation of Their Drug Likeliness Properties

Table 1

Mortar-pestle-induced O-alkylation of β-naphthols under solvent-free conditions.

ReactantsH2SO4
(5 hr)
CTAB
(2 hr)
SDS
(2.5 hr)
TX-100
(3.0 hr)
M.P/B.P
(°C)
12% yield% yield% yield% yield

β-NaphtholMeOH8993909070-71
EtOH9093909035–37
1-PrOH8891919137–39
2-PrOH91949191

1-Bromonaphthalen-2-olMeOH9091899080-81
EtOH8892909064–66
1-PrOH88969089
2-PrOH9194898937–39

1-Chloronaphthalen-2-olMeOH9090938964-65
EtOH9090929056–58
1-PrOH91919188
2-PrOH91919491

1-Iodonaphthalen-2-olMeOH9089919087–89
EtOH9090928835–37
1-PrOH8990968837–39
2-PrOH89899491