Table of Contents
Organic Chemistry International
Volume 2013 (2013), Article ID 582079, 10 pages
http://dx.doi.org/10.1155/2013/582079
Research Article

Synthesis, Characterization, and Biological Activity of 4-(2-Hydroxy-5-(aryl-diazenyl)phenyl)-6-(aryl)pyrimidin-2-ols Derivatives

1Department of Applied Chemistry, Shri Ramdeobaba College of Engineering and Management, Nagpur, Maharashtra 440 013, India
2Department of Applied Chemistry, Guru Nanak Institute of Engineering and Technology, Kalmeshwar, Nagpur, Maharashtra 440 001, India
3Department of Applied Chemistry, G. H. Raisoni Academy of Engineering and Technology, Nagpur, Maharashtra 440 016, India

Received 15 April 2013; Accepted 17 June 2013

Academic Editor: William Setzer

Copyright © 2013 Chandrashekhar P. Pandhurnekar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

With the aim of synthesizing new heterocyclic compounds and exploring biological potency, new series of chalcones, that is, 3-(2-hydroxy-5-(aryl-diazenyl)phenyl)-1-(aryl)prop-2-en-1-one and their pyrimidine derivatives, that is, 4-(2-hydroxy-5-(aryl-diazenyl)phenyl)-6-(aryl)pyrimidin-2-ols were synthesized using different aromatic amines and salicylaldehyde as starting moieties. The structures of newly synthesized compounds were confirmed using different spectroscopic techniques such as IR, 1H-NMR, 13C-NMR, and mass spectral analysis, and elemental analysis. The newly synthesized pyrimidines derivatives were screened for their in vitro antibacterial and antifungal activities. It was observed that some of the newly synthesized compounds had shown promising activity against several bacterial and fungal stains. Anti-bacterial activity and anti-fungal activity studies revealed that pyrimidine derivatives consisting of nitro group in their molecular structure possess better activity than their corresponding chalcones.