Catalytic Synthesis of -Aminonitriles Using Nano Copper Ferrite under Green Conditions

Table 5

Synthesis of α-aminonitriles derivatives in the presence of acidic nano copper ferrite (CuFe₂O₄) (nano copper ferrite (CuFe₂O₄) catalyst with AcOH) and water as green solvent at room temperature.

Entry	Carbonyl compound	Amine	Product	Time (min)	^aYield (%)	Mp (°C)
1				75	92	115–117
2				70	90 (90, 89.5, 89.5, 89)^b	104–106
3				73	92	83–85
4				75	94.5	100–102
5				70	94 (93.5, 93, 93, 92.5)^b	109-110
6				69	91 (91, 90, 90, 89.5)^b	95–97
7				68	94 (94, 93, 92.5, 92)^b	70–73
8				65	93	121–123
9				55	98 (98, 98, 97, 97)^b	90–92
10				50	93 (93, 92.5, 92, 92)^b	73-74
11				81	72	80–83
12				75	75	49–52
13				65	78	110–112
14				62	93	107–109

aIsolated yields. ^bCatalyst was reused over four runs.