In Quest of “Stereoselective Switch” for On-Water Hydrothiolation of Terminal Alkynes Using Different Additives and Green Synthesis of Vicinal Dithioethers

Table 4

Dihydrothiolation of aliphatic alkyne with thiols in water at room temperature.

Entry	[A]	[B]^a	Time (h)	Yield^b (%) [C]
1^c	R^1 = CH3-CH2-CH2	R^2 = Ph	5	88
2	R^1 = CH3-CH2-CH2	R^2 = Ph	5	76
3	R^1 = CH2OAc	R^2 = Ph	6	79
4	R^1 = CH3-CH2-CH2	R^2 = CH3(CH2)6	9	58

a[A] : [B] is 1 : 2.2. bYield represents the product [C] after purification by column chromatography. cD (+)-Glucose (1 equiv) was added.