Table of Contents
Organic Chemistry International
Volume 2014, Article ID 419518, 5 pages
Research Article

Synthesis, Characterization, and Evaluation for Antibacterial and Antifungal Activities of N-Heteroaryl Substituted Benzene Sulphonamides

Synthetic Organic Chemistry Division, Department of Pure and Industrial Chemistry, University of Nigeria, Nigeria

Received 2 May 2014; Revised 6 August 2014; Accepted 6 August 2014; Published 27 November 2014

Academic Editor: Joseph E. Saavedra

Copyright © 2014 Christiana Nonye Igwe and Uchechukwu Chris Okoro. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The synthesis and biological activity of N-heteroaryl substituted benzene sulphonamides (3a–h) were successful. Simple condensation reaction of benzene sulphonyl chloride (1) with substituted heteroaromatic compounds (2a–h) under dry pyridine and acetone gave the target molecules (3a–h) in good to excellent yield. The compounds were characterized using FTIR, 1HNMR, and 13CNMR. The compounds were screened for antibacterial activity against E. coli, Salmonella typhi, P. aeruginosa, B. cereus, K. pneumonia, and Sarcina  lutea and antifungal activity against C. albicans and A. niger. The results of the antimicrobial activity showed improved biological activity against some tested organisms.