TY - JOUR
A2 - Saavedra, Joseph E.
AU - Kasséhin, Urbain C.
AU - Gbaguidi, Fernand A.
AU - Kapanda, Coco N.
AU - McCurdy, Christopher R.
AU - Poupaert, Jacques H.
PY - 2014
DA - 2014/12/10
TI - Insight into the Willgerodt-Kindler Reaction of ω-Haloacetophenone Derivatives: Mechanistic Implication
SP - 486540
VL - 2014
AB - This paper reports efforts aimed at tuning up the synthesis of a compound library centered on the general template 2-amino-1-phenyl-2-thioxoethanone taking the condensation of ω-haloacetophenone, octasulfur, and morpholine as pilot reaction. Considerations about atomic economy were found extremely precious in selecting the best starting halo-reagent. A one-pot practical method based on use of 2-bromo-1-phenylethanone as substrate and N,N-dimethylformamide as solvent can be easily scaled up to gram amounts (72% yield). Based on this synthetic approach, some more specific examples are reported.
SN - 2090-200X
UR - https://doi.org/10.1155/2014/486540
DO - 10.1155/2014/486540
JF - Organic Chemistry International
PB - Hindawi Publishing Corporation
KW -
ER -