Research Article
Water Mediated Synthesis of N′-Arylmethylene-4,5,6,7-tetrahydro-2H-indazole-3-carbohydrazide Library
Table 1
Physicochemical properties of N′-arylmethylene-4,5,6,7-tetrahydro-2H-indazole-3-carbohydrazide derivatives 4a–t.
| Entry | R | Yielda (%) | Mp °C |
| 4a | Ph | 95 | 230–232 | 4b | 4-OCH3 Ph | 91 | 216–218 | 4c | 4-CH3 Ph | 86 | 208–210 | 4d | 3,4-diOCH3 Ph | 86 | 220–222 | 4e | 2,5-diOCH3 Ph | 89 | 212–214 | 4f | 3-Br Ph | 95 | 214–216 | 4g | 4-OH Ph | 91 | 219-220 | 4h | 2-OH Ph | 85 | 226–228 | 4i | 4-N(CH3)2 Ph | 85 | 208–210 | 4j | 3-Cl Ph | 90 | 212–214 | 4k | 4-Cl Ph | 90 | 225-226 | 4l | 2-Cl Ph | 90 | 216–218 | 4m | 4-F Ph | 86 | 226–228 | 4n | 4-NO2 Ph | 80 | 217-218 | 4o | 3-NO2 Ph | 80 | 204–206 | 4p | 3-Pyridyl | 92 | 228–230 | 4q | 2-Furyl | 88 | 214–216 | 4r | 1-Napthyl | 92 | 227–229 | 4s | 3-OH Ph | 93 | 214–216 | 4t | 2-OCH3 Ph | 87 | 223-224 |
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Isolated yield after purification.
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