Research Article

Water Mediated Synthesis of N′-Arylmethylene-4,5,6,7-tetrahydro-2H-indazole-3-carbohydrazide Library

Table 1

Physicochemical properties of N′-arylmethylene-4,5,6,7-tetrahydro-2H-indazole-3-carbohydrazide derivatives 4a–t.

EntryRYielda (%)Mp °C

4aPh95230–232
4b4-OCH3 Ph91216–218
4c4-CH3 Ph86208–210
4d3,4-diOCH3 Ph86220–222
4e2,5-diOCH3 Ph89212–214
4f3-Br Ph95214–216
4g4-OH Ph91219-220
4h2-OH Ph85226–228
4i4-N(CH3)2 Ph85208–210
4j3-Cl Ph90212–214
4k4-Cl Ph90225-226
4l2-Cl Ph90216–218
4m4-F Ph86226–228
4n4-NO2 Ph80217-218
4o3-NO2 Ph80204–206
4p3-Pyridyl92228–230
4q2-Furyl88214–216
4r1-Napthyl92227–229
4s3-OH Ph93214–216
4t2-OCH3 Ph87223-224

Isolated yield after purification.