Table of Contents
Organic Chemistry International
Volume 2014, Article ID 576715, 9 pages
Research Article

Synthesis of Novel Symmetrical and Unsymmetrical o-Phthalic Acid Diamides

Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad College of Engineering, Kukatpally, Hyderabad, Andhra Pradesh 500085, India

Received 23 January 2014; Revised 26 March 2014; Accepted 27 March 2014; Published 5 May 2014

Academic Editor: Joseph E. Saavedra

Copyright © 2014 Padam Praveen Kumar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Phthalic anhydride was treated with secondary amines in acetic acid yielding 2-(diethyl (or) 4-alkylpiperazine or morpholine-1-carbonyl) benzoic acids. The latter were reacted, again, with secondary amines and arylamines by using the coupling reagent HATU and Et3N as a base in DMF giving the novel symmetrical o-phthalic acid diamides , unsymmetrical o-phthalic acid diamides , and primary amidic-secondary amidic containing unsymmetrical o-phthalic acid diamides , respectively.