Synthesis of Novel Symmetrical and Unsymmetrical o-Phthalic Acid Diamides

Table 3

Characterization data, reaction time, and yields of 4a–4e and 5a–5j obtained from 3a–3e and 2a–2e.

Entry	Starting material used		Product obtained	Time (min)	Yield^≠	M.P (°C)
1	3a	2a	4a	40–45	85	>220
2	3b	2b	4b	40–45	85	>220
3	3c	2c	4c	50–55	80	>220
4	3d	2d	4d	50–55	80	>220
5	3e	2e	4e	40–45	80	>220
6	3a	2b	5a	40–45	85	>220
7	3a	2c	5b	50–55	81	110–112
8	3a	2d	5c	50–55	84	115–118
9	3a	2e	5d	50–55	85	80–82
10	3b	2a	5a	40–45	83	>220
11	3b	2c	5e	50–55	84	>220
12	3b	2d	5f	50–55	85	>220
13	3b	2e	5g	60–65	85	85–87
14	3c	2a	5b	60–65	81	110–112
15	3c	2b	5e	50–55	83	>220
16	3c	2d	5h	50–55	85	>220
17	3c	2e	5i	50–55	85	90–92
18	3d	2a	5c	60–65	80	115–118
19	3d	2b	5f	50–55	80	>220
20	3d	2c	5h	40–45	85	>220
21	3d	2e	5j	40–45	83	>220
22	3e	2a	5d	40–45	80	80–82
23	3e	2b	5g	50–55	84	85–87
24	3e	2c	5i	50–55	84	90–92
25	3e	2d	5j	40–45	83	>220

≠Refers to yields of crude products only.