Table of Contents
Organic Chemistry International
Volume 2014, Article ID 748257, 5 pages
http://dx.doi.org/10.1155/2014/748257
Research Article

Synthesis and Antimicrobial Activities of N-(Heteroaryl-substituted)-p-toluenesulphonamides

Department of Pure and Industrial Chemistry, University of Nigeria, Nsukka, Enugu, Nigeria

Received 23 December 2013; Accepted 13 February 2014; Published 15 April 2014

Academic Editor: Ralph Nicholas Salvatore

Copyright © 2014 Ozoh Chinwe Francisca et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A new class of N-(heteroaryl-substituted)-p-toluenesulphonamides has been synthesized exhibiting antibacterial and antifungal properties. The condensation reaction of p-toluenesulphonyl chloride 1 with appropriate substituted amino pyridines 2a–g in acetone furnished N-(heteroaryl-substituted)-p-toluenesulphonamides 3a–g. These derivatives were characterized by IR, 1H-, and 13C-NMR spectroscopy and were screened in vitro against gram-positive bacteria, gram-negative bacteria, and fungi organisms using agar-diffusion method. Results indicated improved biological activities over reference drugs such as Tetracycline (TCN) and Fluconazole (FLU).