A new class of N-(heteroaryl-substituted)-p-toluenesulphonamides has been synthesized exhibiting antibacterial and antifungal properties. The condensation reaction of p-toluenesulphonyl chloride 1 with appropriate substituted amino pyridines 2a&#x2013;g in acetone furnished N-(heteroaryl-substituted)-p-toluenesulphonamides 3a&#x2013;g. These derivatives were characterized by IR, 1H-, and 13C-NMR spectroscopy and were screened in vitro against gram-positive bacteria, gram-negative bacteria, and fungi organisms using agar-diffusion method. Results indicated improved biological activities over reference drugs such as Tetracycline (TCN) and Fluconazole (FLU).

Ozoh Chinwe Francisca

Okoro Uchechukwu Chris

Ugwu David Izuchukwu

Synthesis and Antimicrobial Activities of N-(Heteroaryl-substituted)-p-toluenesulphonamides

An efficient method for the synthesis of N-tert-butyl amides by reaction of nitriles with tert-butyl acetate or tert-butanol is described using oxalic acid dihydrate in solvent-free condition. The result showed that tert-butyl acetate served as a relatively better source of tert-butyl carbocation than tert-butanol.

Masoud Mokhtary

Seyedeh Khadijeh Nasernezhad

An Efficient Method for Synthesis of N-tert-Butyl Amides Using Oxalic Acid Dihydrate in Solvent-Free Condition

Various 4-bromomethylcoumarins (1a-k) were reacted with methyl salicylate to yield 2-(2-oxo-2H-chromen-4-ylmethoxy)-benzoic acid methyl esters (2a-k). Formations of (3a-k) were achieved by using DBU under microwave irradiation. Structures of all the compounds were established on the basis of their spectral data. All the compounds were tested in vitro for their antimicrobial activity and cell cytotoxicity. All the tested compounds (2b-k) and (3a-k) were shown to be better activity against Staphylococcus aureus than the standard Ciprofloxacin. The compound (3k) (R = 6-OMe) was found to be more potent cytotoxic than the standard 5-fluorouracil.

Puttaraju Boregowda

Shivashankar Kalegowda

Vijaykumar Pandurang Rasal

Jagadeeshreddy Eluru

Ebenezer Koyye

Synthesis and Biological Evaluation of 4-(3-Hydroxy-benzofuran-2-yl)coumarins

Some imine derivatives (1a&#x2013;7d) were synthesized using a rapid and an environmentally friendly method with reaction of aromatic aldehydes (a&#x2013;d) and aromatic amines (1&#x2013;7) (in 1&#x2009;:&#x2009;1 molar ratio) in the presence of <svg style="vertical-align:-2.29482pt;width:10px;" id="M1" height="16.6625" version="1.1" viewBox="0 0 10 16.6625" width="10" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg">
	
		
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</svg>-ethoxyethanol as a wetting reagent (2 drops) under solvent-free conditions using microwave heating.

Yunus Bekdemir

K&#xfc;r&#x15f;at Efil

Microwave Assisted Solvent-Free Synthesis of Some Imine Derivatives

A green approach for the synthesis of N-alkyl-2-thiomethyl benzimidazoles 2 (R=CH3, C2H5, CH2Ph) under different conditions has been developed from N-alkyl-2-chloromethyl benzimidazole (i.e., CH3, C2H5, CH2Ph) 1 by reaction with thiourea by physical grinding, or by using green solvents like ethanol and PEG-600, or by using microwave irradiation technique.

S. Srinivas Rao

Ch. Venkata Ramana Reddy

P. K. Dubey

Synthesis of N-Alkyl-2-thiomethyl Benzimidazoles: A Green Approach

A convenient and efficient protocol for the one-pot synthesis of 3,4-dihydropyrimidin-2-(1H)-one/thione derivatives of aldehydes, and 1,3-dicarbonyl compounds with Bismuth (III) sulfate trihydrate as the catalyst was described. We had the advantages of good performance, simplicity, and short time reaction under solvent-free conditions. The catalyst can be repeatedly reused without loss of its activity.

Farhad Hatamjafari

An Efficient One-Pot Multi-Component Synthesis of 3,4-Dihydropyrimidin-2-(1H)-Ones/Thiones Catalyzed by Bismuth (III) Sulfate Trihydrate under Solvent-Free Conditions

Copper ferrite nanomaterial <svg xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg" style="vertical-align:-3.05097pt" id="M3" height="12.3393pt" version="1.1" viewBox="-0.0498162 -9.28833 57.1376 12.3393" width="57.1376pt"><g transform="matrix(.013,0,0,-0.013,0,0)"><use xlink:href="#g50-41"/></g><g transform="matrix(.013,0,0,-0.013,4.654,0)"><use xlink:href="#g190-68"/></g><g transform="matrix(.013,0,0,-0.013,13.331,0)"><use xlink:href="#g190-118"/></g><g transform="matrix(.013,0,0,-0.013,20.26,0)"><use xlink:href="#g190-71"/></g><g transform="matrix(.013,0,0,-0.013,27.163,0)"><use xlink:href="#g190-102"/></g><g transform="matrix(.0091,0,0,-0.0091,32.709,3.001)"><path id="g50-51" d="M414 144C384 79 371 75 317 75H135L276 221C367 316 408 376 408 465C408 570 327 635 237 635C179 635 131 609 100 575L42 494L67 471C94 510 138 565 205 565C277 565 321 517 321 435C321 348 258 270 195 195C146 137 88 81 33 26V0H411C423 44 433 88 446 135L414 144Z"/></g><g transform="matrix(.013,0,0,-0.013,37.655,0)"><use xlink:href="#g190-80"/></g><g transform="matrix(.0091,0,0,-0.0091,47.403,3.001)"><path id="g50-53" d="M462 177V227H365V632H320C217 496 116 350 21 208V177H284V109C284 43 280 38 190 31V0H451V31C369 38 365 43 365 108V177H462ZM284 227H88C155 336 218 430 282 519H284V227Z"/></g><g transform="matrix(.013,0,0,-0.013,52.349,0)"><use xlink:href="#g50-42"/></g></svg> as reusable heterogeneous initiator in the synthesis of &#x3B1;-aminonitriles. The nanocatalyst is easily recovered and its reusability is recorded. Synthesis of &#x3B1;-aminonitriles derivatives by one-pot reaction of different aldehydes with amines and trimethylsilyl cyanides has been developed using nano copper ferrite <svg xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg" style="vertical-align:-3.05097pt" id="M4" height="12.3393pt" version="1.1" viewBox="-0.0498162 -9.28833 57.1376 12.3393" width="57.1376pt"><g transform="matrix(.013,0,0,-0.013,0,0)"><use xlink:href="#g50-41"/></g><g transform="matrix(.013,0,0,-0.013,4.654,0)"><use xlink:href="#g190-68"/></g><g transform="matrix(.013,0,0,-0.013,13.331,0)"><use xlink:href="#g190-118"/></g><g transform="matrix(.013,0,0,-0.013,20.26,0)"><use xlink:href="#g190-71"/></g><g transform="matrix(.013,0,0,-0.013,27.163,0)"><use xlink:href="#g190-102"/></g><g transform="matrix(.0091,0,0,-0.0091,32.709,3.001)"><use xlink:href="#g50-51"/></g><g transform="matrix(.013,0,0,-0.013,37.655,0)"><use xlink:href="#g190-80"/></g><g transform="matrix(.0091,0,0,-0.0091,47.403,3.001)"><use xlink:href="#g50-53"/></g><g transform="matrix(.013,0,0,-0.013,52.349,0)"><use xlink:href="#g50-42"/></g></svg> catalyst under room temperature and green solvent (water as solvent) conditions. &#x3B1;-aminonitriles are important in preparing a wide variety of amino acids, amides, diamines, and nitrogen containing heterocycles.

Ali Gharib

Nader Noroozi Pesyan

Leila Vojdani Fard

Mina Roshani

Catalytic Synthesis of <svg style="vertical-align:-0.1638pt" height="8.1625004" version="1.1" viewBox="0 0 10.7375 8.1625004" width="10.7375" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg"><g transform="matrix(.017,-0,0,-.017,.062,7.9)"><path id="x1D736" d="M505 450h125l-163 -259q-1 -4 -1 -12q0 -19 1 -23q9 -98 41 -98q36 0 58 76l24 -7q-34 -139 -121 -139q-32 0 -57.5 24t-31.5 55q-72 -77 -181 -77q-73 0 -114 44t-41 124q0 118 79 210q79 93 197 93q51 0 86 -27t50 -71zM369 281q0 141 -62 141q-43 0 -95 -84&#xA;q-52 -82 -52 -195q0 -50 15 -83t42 -33q35 0 79 57q43 58 67 121q6 35 6 76z" /></g></svg>-Aminonitriles Using Nano Copper Ferrite <svg style="vertical-align:-3.276pt" height="16.275" version="1.1" viewBox="0 0 73.800003 16.275" width="73.800003" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg"><g transform="matrix(.017,-0,0,-.017,.062,12.137)"><path id="x28" d="M300 -147l-18 -23q-106 71 -159 185.5t-53 254.5v1q0 139 53 252.5t159 186.5l18 -24q-74 -62 -115.5 -173.5t-41.5 -242.5q0 -130 41.5 -242.5t115.5 -174.5z" /></g><g transform="matrix(.017,-0,0,-.017,5.944,12.137)"><path id="x43" d="M614 175l29 -10q-33 -109 -57 -154q-121 -26 -184 -26q-90 0 -160.5 29t-112.5 77t-63.5 105.5t-21.5 119.5q0 157 108 253t277 96q36 0 71.5 -5t69 -13.5t36.5 -8.5q15 -102 20 -150l-29 -8q-20 79 -66.5 114t-128.5 35q-119 0 -187.5 -86t-68.5 -207&#xA;q0 -140 73.5 -227.5t188.5 -87.5q73 0 119.5 37.5t86.5 116.5z" /></g><g transform="matrix(.017,-0,0,-.017,17.248,12.137)"><path id="x75" d="M518 50v-26q-32 -4 -77 -16l-37 -11t-33 -9l-6 6v71q-56 -42 -74 -52q-43 -25 -77 -25q-55 0 -89.5 36.5t-34.5 112.5v196q0 38 -6.5 48.5t-26.5 15.5l-28 6v23q19 1 72 7q59 9 71 11q-3 -31 -3 -145v-135q0 -113 88 -113q59 0 108 48v234q0 38 -8 49t-34 15l-36 6v23&#xA;q44 2 90 8q37 4 67 10v-334q0 -37 8.5 -47t38.5 -12z" /></g><g transform="matrix(.017,-0,0,-.017,26.275,12.137)"><path id="x46" d="M493 503l-29 -4q-13 56 -28 80q-13 22 -35.5 29.5t-78.5 7.5h-76q-22 0 -27.5 -5t-5.5 -27v-238h103q66 0 82.5 12t25.5 62h29v-193h-29q-9 54 -25.5 67t-82.5 13h-103v-181q0 -64 15 -78.5t84 -19.5v-28h-272v28q61 5 74.5 19.5t13.5 78.5v399q0 64 -13 78t-72 19v28&#xA;h440q1 -40 10 -147z" /></g><g transform="matrix(.017,-0,0,-.017,35.267,12.137)"><path id="x65" d="M380 106l15 -22q-42 -52 -87 -74t-76 -22q-89 0 -142 62t-53 151q0 103 66 175q67 73 146 73h1q61 0 105.5 -46.5t44.5 -105.5q0 -16 -4.5 -22.5t-18.5 -9.5q-54 -10 -262 -17q1 -95 46 -143.5t104 -48.5q61 0 115 50zM225 412q-35 0 -64.5 -32.5t-40.5 -90.5q83 0 170 3&#xA;q14 0 19 4.5t5 15.5q1 41 -23.5 70.5t-65.5 29.5z" /></g><g transform="matrix(.012,-0,0,-.012,42.488,16.212)"><path id="x32" d="M412 140l28 -9q0 -2 -35 -131h-373v23q112 112 161 170q59 70 92 127t33 115q0 63 -31 98t-86 35q-75 0 -137 -93l-22 20l57 81q55 59 135 59q69 0 118.5 -46.5t49.5 -122.5q0 -62 -29.5 -114t-102.5 -130l-141 -149h186q42 0 58.5 10.5t38.5 56.5z" /></g><g transform="matrix(.017,-0,0,-.017,48.825,12.137)"><path id="x4F" d="M381 665q131 0 226.5 -93t95.5 -239q0 -158 -96 -253t-238 -95q-137 0 -231 95t-94 238q0 142 92.5 244.5t244.5 102.5zM359 629q-89 0 -151 -74.5t-62 -208.5q0 -141 69 -233t175 -92q90 0 150.5 74t60.5 211q0 152 -69 237.5t-173 85.5z" /></g><g transform="matrix(.012,-0,0,-.012,61.525,16.212)"><path id="x34" d="M456 178h-96v-72q0 -51 12.5 -62.5t72.5 -16.5v-27h-256v27q65 5 78 17t13 62v72h-260v28q182 271 300 426h40v-407h96v-47zM280 225v295h-2q-107 -148 -196 -295h198z" /></g><g transform="matrix(.017,-0,0,-.017,67.862,12.137)"><path id="x29" d="M275 270q0 -296 -211 -440l-19 23q75 62 116.5 174t41.5 243t-42 243t-116 173l19 24q211 -144 211 -440z" /></g></svg> under Green Conditions

A one-pot microwave-assisted synthesis of metallopyrazinoporphyrazines as porphyrazine derivatives 
                  carrying six-membered pyrazine rings annulated at the periphery of the tetrapyrrolic macrocycle is described starting from 2,3-diaminomaleonitrile, 1,2-dicarbonyl compounds, 
                  metal salts, and urea.

Ali Maleki

Ali Hossein Rezayan

One-Pot Synthesis of Metallopyrazinoporphyrazines Using 2,3-Diaminomaleonitrile and 1,2-Dicarbonyl Compounds Accelerated by Microwave Irradiation

On-water hydrothiolation reaction between terminal alkyne and thiol has been probed in the presence of various additives. Aromatic alkynes yield corresponding 1-alkenyl sulfides, whereas aliphatic alkynes undergo double-addition yielding vicinal disulfides in good to excellent yields. Formation of 1-alkenyl sulfides proceeds with a high degree of regioselectivity (via anti-Markovnikov addition), and switching the stereoselectivity between E/Z isomers has been noticeably realized in the presence of different additives/promoters.

Basudeb Basu

Kinkar Biswas

Samir Kundu

Debasish Sengupta

In Quest of &#x201C;Stereoselective Switch&#x201D; for On-Water Hydrothiolation of Terminal Alkynes Using Different Additives and Green Synthesis of Vicinal Dithioethers

Substituted 2-amino-4-aryl-7-hydroxy-4H-chromene-3-carbonitriles (6), 2-amino-4-aryl-4H-benzo[h]chromene-3-carbonitriles (7), and 3-amino-1-aryl-1H-benzo[f]chromenes-2-carbonitriles (8) were prepared, in good yields, via one-pot three-component reactions of aromatic aldehydes (1), malononitrile (2), and resorcinol (3) or &#x3B1;-naphthol (4) or &#x3B2;-naphthol (5) in refluxing ethanol or water in the presence of Rochelle salt as novel green heterogeneous and reusable catalyst.

Awatef Mohamed El-Maghraby

Green Chemistry: New Synthesis of Substituted Chromenes and Benzochromenes via Three-Component Reaction Utilizing Rochelle Salt as Novel Green Catalyst

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