Organic Chemistry International The latest articles from Hindawi © 2018 , Hindawi Limited . All rights reserved. Synthesis and Antiproliferative Activity of Some Quinoline and Oxadiazole Derivatives Thu, 24 Nov 2016 06:18:22 +0000 In continuance of our search for newer antiproliferative agents we report herein the synthesis and antiproliferative studies of two series (5a–j and 10a–c) of heterocyclic compounds. All the new compounds were characterized by IR, NMR, and mass spectral data. The antiproliferative activity of 10 compounds (5a–j) was carried out on HeLa (cervix cancer cell line) and MDA-MB-435 (melanoma) and LC50, TGI, and GI50 were calculated, while the antiproliferative activity of 3 compounds (10a–c) was carried out against nine different panels of nearly 60 cell lines (NCI-60) according to the National Cancer Institute (NCI US) Protocol at 10 μM. 1-(7-Hydroxy-4-methyl-2-oxoquinolin-1(2H)-yl)-3-(4-methoxylphenyl)urea (5j) was found to have antiproliferative activity with GI50 of 35.1 μM against HeLa (cervix cancer cell line) and 60.4 μM against MDA-MB-435 (melanoma), respectively. The compounds 10a, 10b, and 10c showed antiproliferative activity with comparatively higher selectivity towards HOP-92 (Non-Small Cell Lung Cancer) with percent growth inhibitions (GIs) of 34.14, 35.29, and 31.59, respectively. Mohamed Jawed Ahsan, Sunil Shastri, Rita Yadav, Mohd. Zaheen Hassan, Mohammed Afroz Bakht, Surender Singh Jadav, and Sabina Yasmin Copyright © 2016 Mohamed Jawed Ahsan et al. All rights reserved. Synthesis, Structural Elucidation, and Antibacterial Evaluation of Some New Molecules Derived from Coumarin, 1,3,4-Oxadiazole, and Acetamide Wed, 07 Sep 2016 14:33:22 +0000 Because of the reported biological activities of coumarin, 1,3,4-oxadiazole, and acetamides, some new compounds incorporating these moieties were synthesized and evaluated for their biological potential against Gram-positive and Gram-negative bacteria. In the present work, 4-chlororesorcinol (1) and ethyl acetoacetate (2) were mixed in a strong acidic medium to synthesize 6-chloro-7-hydroxy-4-methyl-2-oxo-2H-chromene (3) which was subjected to the intermolecular cyclization after consecutive three steps to synthesize 5-(6-chloro-4-methyl-2-oxo-2H-chromen-7-yl)oxy]-1,3,4-oxadiazol-2-thiol (6). A series of acetamoyl electrophiles, 8a–o, were synthesized from aralkyl/alkyl/aryl amines, 7a–o, in an aqueous basic medium. The final compounds, 9a–o, were synthesized by the reaction of compounds 6 and 8a–o in DMF/NaH. The synthesized compounds were structurally elucidated by spectral data analysis of IR, 1H-NMR, and EIMS. The most of the synthesized compounds remained moderate to excellent antibacterial agents. The molecules, 9e, 9j, and 9k, were the most efficient ones against all the five bacterial strains taken into account. Shahid Rasool, Aziz-ur-Rehman, Muhammad Athar Abbasi, Sabahat Zahra Siddiqui, Syed Adnan Ali Shah, Sidra Hassan, and Irshad Ahmad Copyright © 2016 Shahid Rasool et al. All rights reserved. Synthesis of New Energetic Materials and Ionic Liquids Derived from Metronidazole Thu, 14 Jan 2016 11:23:49 +0000 Simple and efficient synthetic procedures were established for the preparation of new energetic covalent compounds, salts, and protonated ionic liquids based on the readily available antimicrobial agent metronidazole. Some of these materials exhibit the desirable properties of energetic materials and energetic ionic liquids, such as low vapor pressure, low melting point, good chemical and thermal stability, and high energetic content. For each of the relevant compounds prepared, thermal stability was determined by differential scanning calorimetry. Some of these compounds may be considered promising precursors of pharmaceuticals such as antimicrobial, antiparasitic, antifungal, antineoplastic agents, or enzyme inhibitors. Miguel A. Romero Copyright © 2016 Miguel A. Romero. All rights reserved. Synthesis, Characterization, and Application of Poly(N,N′-dibromo-N-ethylnaphthyl-2,7-disulfonamide) as an Efficient Reagent for the Synthesis of 2-Arylbenzimidazole and 2-Aryl-1-arylmethyl-1H-1,3-benzimidazole Derivatives Wed, 06 May 2015 08:27:59 +0000 The condensation of O-phenylenediamine (OPD) with aryl aldehydes is carried out in acetonitrile using poly(N,N′-dibromo-N-ethylnaphthyl-2,7-disulfonamide) (PBNS) as a novel and heterogeneous catalyst. PBNS has some potential advantages which include ease of separation from the reaction mixture by simple filtration, easy preparation, recoverablility, convenience, and stability under normal condition and also is not dangerous as molecular bromine. Vida Saleh, Ardeshir Khazaei, Hamid Abizadeh, and Shahnaz Saednia Copyright © 2015 Vida Saleh et al. All rights reserved. Insight into the Willgerodt-Kindler Reaction of ω-Haloacetophenone Derivatives: Mechanistic Implication Wed, 10 Dec 2014 09:09:15 +0000 This paper reports efforts aimed at tuning up the synthesis of a compound library centered on the general template 2-amino-1-phenyl-2-thioxoethanone taking the condensation of ω-haloacetophenone, octasulfur, and morpholine as pilot reaction. Considerations about atomic economy were found extremely precious in selecting the best starting halo-reagent. A one-pot practical method based on use of 2-bromo-1-phenylethanone as substrate and N,N-dimethylformamide as solvent can be easily scaled up to gram amounts (72% yield). Based on this synthetic approach, some more specific examples are reported. Urbain C. Kasséhin, Fernand A. Gbaguidi, Coco N. Kapanda, Christopher R. McCurdy, and Jacques H. Poupaert Copyright © 2014 Urbain C. Kasséhin et al. All rights reserved. Microwave-Assisted Synthesis of Some 1,3,4-Oxadiazole Derivatives and Evaluation of Their Antibacterial and Antifungal Activity Wed, 03 Dec 2014 06:39:27 +0000 A series of substituted 1,3,4-oxadiazole derivatives (3a–f) and (6a–f) have been synthesized from diphenylacetic acid hydrazide under microwave irradiation in various reaction conditions. The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR, and 1H NMR. These targeted compounds have been tested for their antibacterial and antifungal activities compared to ampicillin and griseofulvin as standard drug. Compounds 3a, 3e, 3f, 6c, 6d, 6e, and 6d exhibited the maximum antibacterial activities while 3b, 3c, 3d, 3e, 6a, 6d, and 6e exhibited the maximum antifungal activities. Deepak Swarnkar, Rakshit Ameta, and Ritu Vyas Copyright © 2014 Deepak Swarnkar et al. All rights reserved. Synthesis, Characterization, and Evaluation for Antibacterial and Antifungal Activities of N-Heteroaryl Substituted Benzene Sulphonamides Thu, 27 Nov 2014 00:10:05 +0000 The synthesis and biological activity of N-heteroaryl substituted benzene sulphonamides (3a–h) were successful. Simple condensation reaction of benzene sulphonyl chloride (1) with substituted heteroaromatic compounds (2a–h) under dry pyridine and acetone gave the target molecules (3a–h) in good to excellent yield. The compounds were characterized using FTIR, 1HNMR, and 13CNMR. The compounds were screened for antibacterial activity against E. coli, Salmonella typhi, P. aeruginosa, B. cereus, K. pneumonia, and Sarcina  lutea and antifungal activity against C. albicans and A. niger. The results of the antimicrobial activity showed improved biological activity against some tested organisms. Christiana Nonye Igwe and Uchechukwu Chris Okoro Copyright © 2014 Christiana Nonye Igwe and Uchechukwu Chris Okoro. All rights reserved. Proline Based Chiral Ionic Liquids for Enantioselective Michael Reaction Thu, 20 Nov 2014 07:14:09 +0000 Chiral ionic liquids, starting from (S)-proline, have been prepared and evaluated the ability of a chiral catalyst. In Michael reaction of trans-β-nitrostyrene and cyclohexanone, all the reactions were carried out under homogeneous conditions without any solvent except for excess cyclohexanone. The chiral ionic liquid catalyst with the positive charge delocalized bulky pyrrolidinium cation shows excellent yields (up to 92%), diastereoselectivities (syn/anti = 96/4), and enantioselectivities (up to 95% ee) and could be reused at least three times without any loss of its catalytic activity. Such results demonstrated a promising new approach for green and economic chiral synthesis by using the chiral ionic liquids as a chiral catalyst and a chiral medium. Kaoru Nobuoka, Satoshi Kitaoka, Tsutomu Kojima, Yuuki Kawano, Kazuya Hirano, Masakazu Tange, Shunsuke Obata, Yuki Yamamoto, Thomas Harran, and Yuich Ishikawa Copyright © 2014 Kaoru Nobuoka et al. All rights reserved. An Efficient, Clean, and Catalyst-Free Synthesis of Fused Pyrimidines Using Sonochemistry Sun, 16 Nov 2014 09:11:09 +0000 In this report, synthesis of indenopyrido[2,3-d]pyrimidine and pyrimido[4,5-b]quinoline derivatives was investigated via one-pot three-component reaction between 6-amino-2-(alkylthio)-pyrimidin-4(3H)one, 1,3-indanedione, or 1,3-cyclohexadione and arylaldehyde under ultrasonic irradiation in ethylene glycol as solvent at 65°C. In these reactions fused pyrimidine derivatives were synthesized with high to excellent yields (82–97%) and short reaction times (10–33 min). M. Mamaghani, K. Tabatabaeian, R. Araghi, A. Fallah, and R. Hossein Nia Copyright © 2014 M. Mamaghani et al. All rights reserved. An Ultrasound Mediated Green Synthesis of Benzimidazolylthiounsaturatednitriles Using Water as a Green Solvent Sun, 09 Nov 2014 07:55:39 +0000 Reaction of 2-cyanothiomethylbenzimidazole  1 with an aromatic aldehydes in water under ultrasonic irradiation for 10–13 min gave the corresponding unsaturated nitriles 2a–h which is an efficient and simple method under green conditions. The unsaturated nitrile derivatives were obtained in 86–98% yield with a short reaction time without any tedious workup procedures. Sadhu Srinivas Rao, Chittireddy Venkata Ramana Reddy, and Pramod Kumar Dubey Copyright © 2014 Sadhu Srinivas Rao et al. All rights reserved. Stereoselective Synthesis of (+)--Conhydrine from R-(+)-Glyceraldehyde Mon, 20 Oct 2014 06:28:25 +0000 Stereoselective synthesis of (+)-α-Conhydrine was accomplished from protected (R)-(+)-glyceraldehyde, a familiar carbohydrate predecessor. Our synthetic strategy featured the following two key reactions. One is Zn-mediated stereoselective aza-Barbier reaction of imine 6 with allyl bromide to afford chiral homoallylic amine 7, and the other is ring-closing metathesis. Nageshwar Rao Penumati and Nagaiah Kommu Copyright © 2014 Nageshwar Rao Penumati and Nagaiah Kommu. All rights reserved. Water Mediated Synthesis of N′-Arylmethylene-4,5,6,7-tetrahydro-2H-indazole-3-carbohydrazide Library Wed, 15 Oct 2014 11:41:54 +0000 A novel two-step synthesis of 4,5,6,7-tetrahydro-2H-indazole-3-carbohydrazide has been developed. The library of N′-arylmethylene-4,5,6,7-tetrahydro-2H-indazole-3-carbohydrazide was generated by coupling of hydrazide to various aromatic and heterocyclic aldehydes in water media at ambient temperature with great flexibility regarding reaction time and yield. Mahesh M. Savant, Akshay M. Pansuriya, Chirag V. Bhuva, Naval Kapuriya, and Yogesh T. Naliapara Copyright © 2014 Mahesh M. Savant et al. All rights reserved. Microwave-Assisted Three-Component “Catalyst and Solvent-Free” Green Protocol: A Highly Efficient and Clean One-Pot Synthesis of Tetrahydrobenzo[b]pyrans Wed, 17 Sep 2014 12:26:34 +0000 A green and highly efficient method has been developed for the one-pot synthesis of tetrahydrobenzo[b]pyrans via a three-component condensation of aldehydes, 1,3-cyclic diketones, and malononitrile under MW irradiation without using any catalyst and solvent. This transformation presumably occurs by a sequential Knoevenagel condensation, Michael addition, and intramolecular cyclization. Operational simplicity, solvent and catalyst-free conditions, the compatibility with various functional groups, nonchromatographic purification technique, and high yields are the notable advantages of this procedure. Sougata Santra, Matiur Rahman, Anupam Roy, Adinath Majee, and Alakananda Hajra Copyright © 2014 Sougata Santra et al. All rights reserved. A Novel Regiospecific Synthesis of 1-Chloro-2-arylcyclohexenes Thu, 10 Jul 2014 11:33:12 +0000 An efficient high yielding chemoselective synthesis of eleven novel 1-chloro-2-arylcyclohexenes employing the Suzuki cross coupling of 1-bromo-2-chlorocyclohexene with eleven different aryl boronic acids and Pd(dppf) catalyst is reported. Lokesh Krishnappa and HariPrasad Suresh Copyright © 2014 Lokesh Krishnappa and HariPrasad Suresh. All rights reserved. Kinetic and Mechanistic Investigation of Pyrano[2,3-d]pyrimidine Formation in the Presence of Catalyst under Novel One-Pot Three-Component Reaction Sun, 11 May 2014 12:18:59 +0000 Sodium acetate was applied as an efficient catalyst for the one-pot, three-component condensation reactions consisting of 4-nitrobenzaldehyde 2, malononitrile 3, and thiobarbituric acid 1. Use of nontoxic reaction components, short reaction times, environmental, easy work-up, and high yields are some remarkable advantages of this method. Kinetics and mechanism of the reaction were spectrally studied and the second order rate constant (kovr = k1) was automatically calculated by the standard equations contained within the program. The second order rate constant [Ln(kovr = k1), Ln(kovr = k1)/T] that depended on reciprocal temperature was in good agreement with the Arrhenius and Eyring equations, respectively. This data provided the suitable plots for calculating the activation energy and parameters (Ea, ΔG‡, ΔS‡, and ΔH‡) of the reaction. Furthermore, from studying the effects of solvent, concentration, and catalyst on the reaction rate, useful information was obtained regarding the mechanism. The results showed that the first step of the reaction mechanism is a rate determining step (RDS). The proposed mechanism was confirmed in accordance with the experimental data and also the steady state approximation. Sayyed Mostafa Habibi-Khorassani, Malek Taher Maghsoodlou, Mehdi Shahraki, Sadegh Talaiefar, and Jasem Aboonajmi Copyright © 2014 Sayyed Mostafa Habibi-Khorassani et al. All rights reserved. Synthesis of Ibuprofen Using Silica-Supported Preyssler Nanoparticles as an Eco-Friendly, Inexpensive, and Efficient Catalyst Tue, 06 May 2014 07:27:42 +0000 This paper describes an alternative and simple procedure for the synthesis of Ibuprofen using Silica-Supported Preyssler Nanoparticles (H14[NaP5W30O110]/SiO2) (SPNPs), as an eco-friendly, inexpensive, and efficient catalyst. High yields, simplicity of operation, and easy work-up procedure are some advantages of this protocol. Silica-Supported Preyssler Nanoparticles (H14[NaP5W30O110]/SiO2) (SPNPs) offer the advantages of a higher hydrolytic and thermal stability. The salient features of Preyssler’s anion are availability, nontoxicity and reusability. We believe this methodology can find usefulness in organic synthesis. Ali Gharib, Nader Noroozi Pesyan, Leila Vojdani Fard, and Mina Roshani Copyright © 2014 Ali Gharib et al. All rights reserved. Synthesis of Novel Symmetrical and Unsymmetrical o-Phthalic Acid Diamides Mon, 05 May 2014 00:00:00 +0000 Phthalic anhydride was treated with secondary amines in acetic acid yielding 2-(diethyl (or) 4-alkylpiperazine or morpholine-1-carbonyl) benzoic acids. The latter were reacted, again, with secondary amines and arylamines by using the coupling reagent HATU and Et3N as a base in DMF giving the novel symmetrical o-phthalic acid diamides , unsymmetrical o-phthalic acid diamides , and primary amidic-secondary amidic containing unsymmetrical o-phthalic acid diamides , respectively. Padam Praveen Kumar, Yervala Dathu Reddy, Chittireddy Venkata Ramana Reddy, Bhoomireddy Rama Devi, and Pramod Kumar Dubey Copyright © 2014 Padam Praveen Kumar et al. All rights reserved. Glycerol Containing Triacetylborate Mediated Syntheses of Novel 2-Heterostyryl Benzimidazole Derivatives: A Green Approach Sun, 27 Apr 2014 08:20:57 +0000 A very simple, mild, efficient, and novel green methodology has been developed for the syntheses of some 2-hetero/styryl-benzimidazoles. Title compounds were synthesized by the condensation of -phenylenediamine with cinnamic acids at 150–180°C for 5-6 h using glycerol containing triacetylborate (10–20 mol%) as the reaction medium. In an alternative approach, condensation of 2-methylbenzimidazole derivatives with aromatic aldehydes was done using glycerol containing triacetylborate (10–20 mol%) as the reaction medium. Ashok Kumar Taduri, P. N. Kishore Babu, and B. Rama Devi Copyright © 2014 Ashok Kumar Taduri et al. All rights reserved. Synthesis and Antimicrobial Activities of N-(Heteroaryl-substituted)-p-toluenesulphonamides Tue, 15 Apr 2014 08:13:37 +0000 A new class of N-(heteroaryl-substituted)-p-toluenesulphonamides has been synthesized exhibiting antibacterial and antifungal properties. The condensation reaction of p-toluenesulphonyl chloride 1 with appropriate substituted amino pyridines 2a–g in acetone furnished N-(heteroaryl-substituted)-p-toluenesulphonamides 3a–g. These derivatives were characterized by IR, 1H-, and 13C-NMR spectroscopy and were screened in vitro against gram-positive bacteria, gram-negative bacteria, and fungi organisms using agar-diffusion method. Results indicated improved biological activities over reference drugs such as Tetracycline (TCN) and Fluconazole (FLU). Ozoh Chinwe Francisca, Okoro Uchechukwu Chris, and Ugwu David Izuchukwu Copyright © 2014 Ozoh Chinwe Francisca et al. All rights reserved. An Efficient Method for Synthesis of N-tert-Butyl Amides Using Oxalic Acid Dihydrate in Solvent-Free Condition Tue, 08 Apr 2014 07:04:06 +0000 An efficient method for the synthesis of N-tert-butyl amides by reaction of nitriles with tert-butyl acetate or tert-butanol is described using oxalic acid dihydrate in solvent-free condition. The result showed that tert-butyl acetate served as a relatively better source of tert-butyl carbocation than tert-butanol. Masoud Mokhtary and Seyedeh Khadijeh Nasernezhad Copyright © 2014 Masoud Mokhtary and Seyedeh Khadijeh Nasernezhad. All rights reserved. Synthesis and Biological Evaluation of 4-(3-Hydroxy-benzofuran-2-yl)coumarins Thu, 27 Mar 2014 08:25:33 +0000 Various 4-bromomethylcoumarins (1a-k) were reacted with methyl salicylate to yield 2-(2-oxo-2H-chromen-4-ylmethoxy)-benzoic acid methyl esters (2a-k). Formations of (3a-k) were achieved by using DBU under microwave irradiation. Structures of all the compounds were established on the basis of their spectral data. All the compounds were tested in vitro for their antimicrobial activity and cell cytotoxicity. All the tested compounds (2b-k) and (3a-k) were shown to be better activity against Staphylococcus aureus than the standard Ciprofloxacin. The compound (3k) (R = 6-OMe) was found to be more potent cytotoxic than the standard 5-fluorouracil. Puttaraju Boregowda, Shivashankar Kalegowda, Vijaykumar Pandurang Rasal, Jagadeeshreddy Eluru, and Ebenezer Koyye Copyright © 2014 Puttaraju Boregowda et al. All rights reserved. Microwave Assisted Solvent-Free Synthesis of Some Imine Derivatives Wed, 26 Mar 2014 12:00:46 +0000 Some imine derivatives (1a–7d) were synthesized using a rapid and an environmentally friendly method with reaction of aromatic aldehydes (a–d) and aromatic amines (1–7) (in 1 : 1 molar ratio) in the presence of -ethoxyethanol as a wetting reagent (2 drops) under solvent-free conditions using microwave heating. Yunus Bekdemir and Kürşat Efil Copyright © 2014 Yunus Bekdemir and Kürşat Efil. All rights reserved. Synthesis of N-Alkyl-2-thiomethyl Benzimidazoles: A Green Approach Mon, 17 Mar 2014 13:06:20 +0000 A green approach for the synthesis of N-alkyl-2-thiomethyl benzimidazoles 2 (R=CH3, C2H5, CH2Ph) under different conditions has been developed from N-alkyl-2-chloromethyl benzimidazole (i.e., CH3, C2H5, CH2Ph) 1 by reaction with thiourea by physical grinding, or by using green solvents like ethanol and PEG-600, or by using microwave irradiation technique. S. Srinivas Rao, Ch. Venkata Ramana Reddy, and P. K. Dubey Copyright © 2014 S. Srinivas Rao et al. All rights reserved. An Efficient One-Pot Multi-Component Synthesis of 3,4-Dihydropyrimidin-2-(1H)-Ones/Thiones Catalyzed by Bismuth (III) Sulfate Trihydrate under Solvent-Free Conditions Thu, 13 Mar 2014 00:00:00 +0000 A convenient and efficient protocol for the one-pot synthesis of 3,4-dihydropyrimidin-2-(1H)-one/thione derivatives of aldehydes, and 1,3-dicarbonyl compounds with Bismuth (III) sulfate trihydrate as the catalyst was described. We had the advantages of good performance, simplicity, and short time reaction under solvent-free conditions. The catalyst can be repeatedly reused without loss of its activity. Farhad Hatamjafari Copyright © 2014 Farhad Hatamjafari. All rights reserved. Catalytic Synthesis of -Aminonitriles Using Nano Copper Ferrite under Green Conditions Wed, 12 Mar 2014 15:39:38 +0000 Copper ferrite nanomaterial as reusable heterogeneous initiator in the synthesis of α-aminonitriles. The nanocatalyst is easily recovered and its reusability is recorded. Synthesis of α-aminonitriles derivatives by one-pot reaction of different aldehydes with amines and trimethylsilyl cyanides has been developed using nano copper ferrite catalyst under room temperature and green solvent (water as solvent) conditions. α-aminonitriles are important in preparing a wide variety of amino acids, amides, diamines, and nitrogen containing heterocycles. Ali Gharib, Nader Noroozi Pesyan, Leila Vojdani Fard, and Mina Roshani Copyright © 2014 Ali Gharib et al. All rights reserved. One-Pot Synthesis of Metallopyrazinoporphyrazines Using 2,3-Diaminomaleonitrile and 1,2-Dicarbonyl Compounds Accelerated by Microwave Irradiation Thu, 27 Feb 2014 13:20:32 +0000 A one-pot microwave-assisted synthesis of metallopyrazinoporphyrazines as porphyrazine derivatives carrying six-membered pyrazine rings annulated at the periphery of the tetrapyrrolic macrocycle is described starting from 2,3-diaminomaleonitrile, 1,2-dicarbonyl compounds, metal salts, and urea. Ali Maleki and Ali Hossein Rezayan Copyright © 2014 Ali Maleki and Ali Hossein Rezayan. All rights reserved. In Quest of “Stereoselective Switch” for On-Water Hydrothiolation of Terminal Alkynes Using Different Additives and Green Synthesis of Vicinal Dithioethers Thu, 13 Feb 2014 16:02:51 +0000 On-water hydrothiolation reaction between terminal alkyne and thiol has been probed in the presence of various additives. Aromatic alkynes yield corresponding 1-alkenyl sulfides, whereas aliphatic alkynes undergo double-addition yielding vicinal disulfides in good to excellent yields. Formation of 1-alkenyl sulfides proceeds with a high degree of regioselectivity (via anti-Markovnikov addition), and switching the stereoselectivity between E/Z isomers has been noticeably realized in the presence of different additives/promoters. Basudeb Basu, Kinkar Biswas, Samir Kundu, and Debasish Sengupta Copyright © 2014 Basudeb Basu et al. All rights reserved. Green Chemistry: New Synthesis of Substituted Chromenes and Benzochromenes via Three-Component Reaction Utilizing Rochelle Salt as Novel Green Catalyst Thu, 30 Jan 2014 09:17:51 +0000 Substituted 2-amino-4-aryl-7-hydroxy-4H-chromene-3-carbonitriles (6), 2-amino-4-aryl-4H-benzo[h]chromene-3-carbonitriles (7), and 3-amino-1-aryl-1H-benzo[f]chromenes-2-carbonitriles (8) were prepared, in good yields, via one-pot three-component reactions of aromatic aldehydes (1), malononitrile (2), and resorcinol (3) or α-naphthol (4) or β-naphthol (5) in refluxing ethanol or water in the presence of Rochelle salt as novel green heterogeneous and reusable catalyst. Awatef Mohamed El-Maghraby Copyright © 2014 Awatef Mohamed El-Maghraby. All rights reserved. An Efficient and Green Method for Synthesis of 2,4,5-Triarylimidazoles without Use of Any Solvent, Catalyst, or Solid Surface Tue, 10 Dec 2013 11:23:55 +0000 An efficient and green method for synthesis of 2,4,5-triarylimidazoles without use of any catalyst or solvent has been developed simply by heating (at 130°C) of mixtures of 1,2-diketone, aromatic aldehyde, and ammonium acetate in 1 : 1 : 3 mole ratio. Swati Samanta, Saheli Sarkar, Rammohan Pal, and Asok K. Mallik Copyright © 2013 Swati Samanta et al. All rights reserved. Synthesis of Pyrazine Substituted 1,3,4-Thiadiazole Derivatives and Their Anticonvulsant Activity Wed, 04 Dec 2013 10:14:46 +0000 The synthesis of new pyrazine substituted 1,3,4-thiadiazole derivatives was carried out in good yield by the reaction of pyrazine substituted 1,3,4-thiadiazoles with various sulfonyl chlorides. A chemical structure of all the new compounds was confirmed by 1H NMR and mass spectral data. The new compounds were screened for their anticonvulsant activity against maximal electroshock (MES) seizure method. Rotarod method was employed to determine the neurotoxicity. Few compounds showed significant changes in anticonvulsant activity. The same compounds showed no neurotoxicity at the maximum dose administered (100 mg/kg). Kikkeri P. Harish, Kikkeri N. Mohana, and Lingappa Mallesha Copyright © 2013 Kikkeri P. Harish et al. All rights reserved.