Recombinant Activated Factor VII (rFVIIa) in the Management of Major Obstetric Haemorrhage: A Case Series and a Proposed Guideline for Use

Table 3

Coagulation parameters before and after the administration of rFVIIa for major obstetric haemorrhage. Normal ranges: Prothrombin time 10–13 seconds; Activated partial thromboplastin time 25–37 seconds; Fibrinogen 2.1–4.8 seconds.

Pt no.	Prothrombin time		Activated partial		Platelet count		Fibrinogen
	(seconds)		thromboplastin time (seconds)		(×10^9/L)		(g/L)
	Pre	Post	Pre	Post	Pre	Post	Pre	Post
1	14	9	30	30	93	96	1.7	1.5
2	21	13	49	33	106	85	1.4	2.6
3	16	10	52	29	129	103	0.9	2.4
4	15	10	34	25	89	93	0.9	1.9
5	16	11	64	57	160	125	1.3	1.7
6	18	11	60	31	68	48	0.4	1.4
7	29	12	160	93	6	22	0.6	0.9
8	15	10	34	37	48	45	1.5	2.1
9	15	9	39	30	89	119	2	2.1
10	15	9	60	30	64	69	0.9	3.6
11	15	9	50	37	76	62	0.9	0.8
12	13	10	50	35	35	57	2.1	2.3
13	14	28	31	150	308	28	4.1	1.3
14	9.2	6.8	101	41	51	34	1.9	3.36
15	16.4	10.6	21	26.5	327	88	2.6	2
Median	15	10	50	33	89	69	1.4	2.0
P-values*	0.007		0.025		0.188		0.073

*Wilcoxon signed-rank test is shown.