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Obstetrics and Gynecology International
Volume 2009, Article ID 956935, 3 pages
http://dx.doi.org/10.1155/2009/956935
Case Report

Prolonged Hypercalcemia Following Resection of Dysgerminoma: A Case Report

1Department of Pediatric Endocrinology, Rainbow Babies & Children's Hospital, 11100 Euclid Avenue, Cleveland, OH 44106, USA
2Department of Gynecological Oncology, University Hospitals, 11100 Euclid Avenue, Cleveland, OH 44106, USA

Received 17 May 2009; Accepted 21 September 2009

Academic Editor: Liselotte Mettler

Copyright © 2009 Abigail Wald et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Hypercalcemia is a rare but potentially dangerous complication of pediatric cancer. Of the dysgerminoma cases reported to date, associated hypercalcemia is corrected within 2–7 days of tumor resection. Case. A 13-year-old female with an ovarian dysgerminoma was found to be hypercalcemic on presentation. Following dysgerminoma resection, moderate hypercaclemia persisted for 7 days and calcium remained mildly elevated for an additional 7 days. PTHrP was undetectable. Immunolocalization studies indicated that 1 𝛼 -hydroxylase was expressed in dysgerminoma tissue but 1,25 ( O H ) 2 D 3 was not elevated. Conclusion. Persistently elevated calcium levels following tumor resection suggests that this case involves a previously undescribed mechanism. Elucidation of this mechanism may offer new insights into tumor biology and opportunities for therapeutic correction of hypercalcemia in this patient population.