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Obstetrics and Gynecology International
Volume 2010 (2010), Article ID 379534, 4 pages
http://dx.doi.org/10.1155/2010/379534
Case Report

Trisomy 9 Mosaicism Diagnosed In Utero

1Department of Maternal-Fetal and Neonatal Medicine, National Center for Child Health and Development, Tokyo 157-8535, Japan
2Department of Clinical Genetics and Molecular Medicine, National Center for Child Health and Development, Tokyo 157-8535, Japan

Received 1 February 2010; Accepted 23 June 2010

Academic Editor: Joe Leigh Simpson

Copyright © 2010 Hironori Takahashi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We present three cases of trisomy 9 mosaicism diagnosed by amniocentesis with ongoing pregnancies after referral to our center due to fetal abnormalities. Two cases were associated with severe fetal growth restriction (FGR), each of which resulted in an intrauterine fetal demise (IUFD) in the third trimester. The other case involved mild FGR with a congenital diaphragmatic hernia and resulted in a live birth with severe development delay. A major prenatal finding of trisomy 9 mosaicism is FGR. Fetuses with trisomy 9 mosaicism can rarely survive in the case of severe FGR.