Trisomy 9 Mosaicism Diagnosed In Utero

Table 2

Characteristics and outcomes of reported cases of prenatal trisomy 9 mosaicism.

Case	Reference	Maternal age (years)	Time of exam (weeks)	Trigger of detection	FGR	Other fetal; findings	Outcomes
1	Bureau et al. [8]	24	36	CNS anomaly	−	Dandy-Walker variant	Liveborn, death at 2 weeks
2	Saura et al. [3]	28	30	PDA, polyhydramnios	−	PDA	Liveborn at 35 weeks
3		29	33	FGR	+	—	Alive at 21 months; severe developmental delay
4	Greenberg et al. [9]	39	16	AAMA	−	—	Liveborn at term
5	Hsu et al. [10]	48	NA	AAMA	−	—	Normal development at 3 years, 8 months
6		42	NA	AAMA	−	—	Liveborn at 23 weeks; death at 4 days
7		38	NA	AAMA	+	Multiple anomalies (no details)	Liveborn at term
8	Sherer et al. [11]	20	31	FGR	Mild	Right hydronephrosis	liveborn, death at 6 weeks
9	Smoleniec et al. [12]	28	34	Severe FGR	Severe	—	IUFD at 34 weeks
10	Case 1	35	29	Severe FGR	Severe	—	IUFD at 33 weeks
11	Case 2 in [5]	36	31	CDH	Mild	Left-sided congenital diaphragmatic hernia	Alive at 4 years; severe developmental delay
12	Case 3	41	24	Severe FGR	Severe	—	IUFD at 38 weeks

AAMA: amniocentesis with advanced maternal age; CNS: central nerve system; FGR: fetal growth restriction; IUFD: intrauterine fetal demise; PDA: patent ductus arteriosus; NA: not available.