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Obstetrics and Gynecology International
Volume 2010, Article ID 638165, 7 pages
Review Article

Controversies in the Management of Endometrial Cancer

1Division of Gynecologic Oncology, Catholic University of Sacred Heart, 00168 Rome, Italy
2Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA

Received 20 December 2009; Revised 8 April 2010; Accepted 10 April 2010

Academic Editor: Enrique Hernandez

Copyright © 2010 V. Masciullo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Endometrial cancer (EC) remains the most common malignancy of the female genital tract. The median age at diagnosis is the sixth decade, with abnormal uterine bleeding at the presentation in 90% of the patients. Surgical treatment, including complete hysterectomy, removal of remaining adnexal structures, and an appropriate surgical staging, represents the milestone of curative therapy for patients with EC. Adjuvant therapy is necessary in patients at high risk of recurrence. Conservative treatment approaches should be used in selected cases for women with a desire of fertility preservation. This review summarizes the management of EC and discusses current controversies regarding the role of lymphadenectomy and radiotherapy in patients with intermediate-risk tumors confined to the uterus.