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Obstetrics and Gynecology International
Volume 2010, Article ID 638165, 7 pages
http://dx.doi.org/10.1155/2010/638165
Review Article

Controversies in the Management of Endometrial Cancer

1Division of Gynecologic Oncology, Catholic University of Sacred Heart, 00168 Rome, Italy
2Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA

Received 20 December 2009; Revised 8 April 2010; Accepted 10 April 2010

Academic Editor: Enrique Hernandez

Copyright © 2010 V. Masciullo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. N. Bakkum-Gamez, J. Gonzalez-Bosquet, N. N. Laack, A. Mariani, and S. C. Dowdy, “Current issues in the management of endometrial cancer,” Mayo Clinic Proceedings, vol. 83, no. 1, pp. 97–112, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Brand, J. Dubuc-Lissoir, T. G. Ehlen, and M. Plante, “Diagnosis of Endometrial cancer in women with abnormal vaginal bleeding,” Journal of the Society of Obstetricians and Gynaecologists of Canada, vol. 22, no. 1, pp. 102–104, 2000. View at Google Scholar
  3. National Cancer Institute of Canada, Canadian Cancer Statistics, Toronto, Canada 1998.
  4. E. R. Evans-Metcalf, S. E. Brooks, F. R. Reale, and S. P. Baker, “Profile of women 45 years of age and younger with endometrial cancer,” Obstetrics and Gynecology, vol. 91, no. 3, pp. 349–354, 1998. View at Publisher · View at Google Scholar · View at Scopus
  5. B. N. Tran, P. P. Connell, S. Waggoner, J. Rotmensch, and A. J. Mundt, “Characteristics and outcome of endometrial carcinoma patients age 45 years and younger,” American Journal of Clinical Oncology, vol. 23, no. 5, pp. 476–480, 2000. View at Publisher · View at Google Scholar · View at Scopus
  6. F. Amant, P. Moerman, P. Neven, D. Timmerman, E. van Limbergen, and I. Vergote, “Endometrial cancer,” Lancet, vol. 366, no. 9484, pp. 491–505, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. H. Klip, C. W. Burger, P. Kenemans, and F. E. Van Leeuwen, “Cancer risk associated with subfertility and ovulation induction: a review,” Cancer Causes and Control, vol. 11, no. 4, pp. 319–344, 2000. View at Publisher · View at Google Scholar · View at Scopus
  8. A. N. Viswanathan, D. Feskanich, I. de Vivo et al., “Smoking and the risk of endometrial cancer: results from the nurses' health study,” International Journal of Cancer, vol. 114, no. 6, pp. 996–1001, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  9. A. Jemal, R. Siegel, E. Ward et al., “Cancer statistics, 2008,” CA Cancer Journal for Clinicians, vol. 58, no. 2, pp. 71–96, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  10. D. M. Boruta II, P. A. Gehrig, A. N. Fader, and A. B. Olawaiye, “Management of women with uterine papillary serous cancer: a Society of Gynecologic Oncology (SGO) review,” Gynecologic Oncology, vol. 115, no. 1, pp. 142–153, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  11. J. V. Bokhman, “Two pathogenetic types of endometrial carcinoma,” Gynecologic Oncology, vol. 15, no. 1, pp. 10–17, 1983. View at Google Scholar · View at Scopus
  12. R. A. Soslow, J. P. Bissonnette, A. Wilton et al., “Clinicopathologic analysis of 187 high-grade endometrial carcinomas of different histologic subtypes: similar outcomes belie distinctive biologic differences,” American Journal of Surgical Pathology, vol. 31, no. 7, pp. 979–987, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  13. W. T. Creasman, “Endometrial cancer: incidence, prognostic factors, diagnosis, and treatment,” Seminars in Oncology, vol. 24, no. 1, pp. 140–150, 1997. View at Google Scholar · View at Scopus
  14. P. J. DiSaia and W. T. Creasman, “Endometrial hyperplasia/estrogen therapy,” in Clinical Gynecologic Oncology, p. 111, Mosby-Year Book, Baltimore, Md, USA, 1997. View at Google Scholar
  15. T. Justin Clark, D. Voit, J. K. Gupta, C. Hyde, F. Song, and K. S. Khan, “Accuracy of hysteroscopy in the diagnosis of endometrial cancer and hyperplasia: a systematic quantitative review,” Journal of the American Medical Association, vol. 288, no. 13, pp. 1610–1621, 2002. View at Google Scholar · View at Scopus
  16. R. Bedner and I. Rzepka-Górska, “Hysteroscopy with directed biopsy versus dilatation and curettage for the diagnosis of endometrial hyperplasia and cancer in perimenopausal women,” European Journal of Gynaecological Oncology, vol. 28, no. 5, pp. 400–402, 2007. View at Google Scholar · View at Scopus
  17. B. Karlsson, S. Granberg, M. Wikland et al., “Transvaginal ultrasonography of the endometrium in women with postmenopausal bleeding—a Nordic multicenter study,” American Journal of Obstetrics and Gynecology, vol. 172, no. 5, pp. 1488–1494, 1995. View at Publisher · View at Google Scholar · View at Scopus
  18. Y. Minagawa, S. Sato, M. Ito, Y. Onohara, S. Nakamoto, and J. Kigawa, “Transvaginal ultrasonography and endometrial cytology as a diagnostic schema for endometrial cancer,” Gynecologic and Obstetric Investigation, vol. 59, no. 3, pp. 149–154, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  19. K. Kinkel, Y. Kaji, K. K. Yu et al., “Radiologic staging in patients with endometrial cancer: a meta-analysis,” Radiology, vol. 212, no. 3, pp. 711–718, 1999. View at Google Scholar · View at Scopus
  20. L. Savelli, M. Ceccarini, M. Ludovisi et al., “Preoperative local staging of endometrial cancer: transvaginal sonography vs. magnetic resonance imaging,” Ultrasound in Obstetrics and Gynecology, vol. 31, no. 5, pp. 560–566, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  21. M. Montejo, T. L. Werner, and D. Gaffney, “Current challenges in clinical management of endometrial cancer,” Advanced Drug Delivery Reviews, vol. 61, no. 10, pp. 883–889, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  22. C. Merisio, R. Berretta, A. de Ioris et al., “Endometrial cancer in patients with preoperative diagnosis of atypical endometrial hyperplasia,” European Journal of Obstetrics Gynecology and Reproductive Biology, vol. 122, no. 1, pp. 107–111, 2005. View at Publisher · View at Google Scholar · View at PubMed
  23. T. C. Randall and R. J. Kurman, “Progestin treatment of atypical hyperplasia and well-differentiated carcinoma of the endometrium in women under age 40,” Obstetrics and Gynecology, vol. 90, no. 3, pp. 434–440, 1997. View at Publisher · View at Google Scholar
  24. C. L. Trimble, J. Kauderer, R. Zaino et al., “Concurrent endometrial carcinoma in women with a biopsy diagnosis of atypical endometrial hyperplasia: a gynecologic oncology group study,” Cancer, vol. 106, no. 4, pp. 812–819, 2006. View at Publisher · View at Google Scholar · View at PubMed
  25. D. Wildemeersch and M. Dhont, “Treatment of nonatypical and atypical endometrial hyperplasia with a levonorgestrel-releasing intrauterine system,” American Journal of Obstetrics and Gynecology, vol. 188, no. 5, pp. 1297–1298, 2003. View at Publisher · View at Google Scholar · View at Scopus
  26. F. J. Montz, R. E. Bristow, A. Bovicelli, R. Tomacruz, and R. J. Kurman, “Intrauterine progesterone treatment of early endometrial cancer,” American Journal of Obstetrics and Gynecology, vol. 186, no. 4, pp. 651–657, 2002. View at Publisher · View at Google Scholar · View at Scopus
  27. A. A. Shamshirsaz, M. Withiam-Leitch, K. Odunsi, T. Baker, P. J. Frederick, and S. Lele, “Young patients with endometrial carcinoma selected for conservative treatment: a need for vigilance for synchronous ovarian carcinomas, case report and literature review,” Gynecologic Oncology, vol. 104, no. 3, pp. 757–760, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  28. International Federation of Gynecology and Obstetrics, “Corpus cancer staging,” The International Journal of Gynecology & Obstetrics, vol. 28, pp. 189–190, 1989. View at Google Scholar
  29. ASTEC/EN.5 Study Group, “Adjuvant external beam radiotherapy in the treatment of endometrial cancer (MRC ASTEC and NCIC CTG EN.5 randomised trials): pooled trial results, systematic review, and meta-analysis,” Lancet, vol. 373, no. 9658, pp. 137–146, 2009. View at Google Scholar
  30. Y.-C. Yang, C.-C. Wu, C.-P. Chen, C.-L. Chang, and K.-L. Wang, “Reevaluating the safety of fertility-sparing hormonal therapy for early endometrial cancer,” Gynecologic Oncology, vol. 99, no. 2, pp. 287–293, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  31. I. Mazzon, G. Corrado, V. Masciullo, D. Morricone, G. Ferrandina, and G. Scambia, “Conservative surgical management of stage IA endometrial carcinoma for fertility preservation,” Fertility and Sterility, vol. 93, no. 4, pp. 1286–1289, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  32. Y. B. Kim, C. H. Holschneider, K. Ghosh, R. K. Nieberg, and F. J. Montz, “Progestin alone as primary treatment of endometrial carcinoma in premenopausal women: report of seven cases and review of the literature,” Cancer, vol. 79, no. 2, pp. 320–327, 1997. View at Publisher · View at Google Scholar · View at Scopus
  33. W. H. Gotlieb, M. E. Beiner, B. Shalmon et al., “Outcome of fertility-sparing treatment with progestins in young patients with endometrial cancer,” Obstetrics and Gynecology, vol. 102, no. 4, pp. 718–725, 2003. View at Publisher · View at Google Scholar · View at Scopus
  34. P. T. Ramirez, M. Frumovitz, D. C. Bodurka, C. C. Sun, and C. Levenback, “Hormonal therapy for the management of grade 1 endometrial adenocarcinoma: a literature review,” Gynecologic Oncology, vol. 95, no. 1, pp. 133–138, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  35. S.-Y. Huang, S.-M. Jung, K.-K. Ng, Y.-C. Chang, and C.-H. Lai, “Ovarian metastasis in a nulliparous woman with endometrial adenocarcinoma failing conservative hormonal treatment,” Gynecologic Oncology, vol. 97, no. 2, pp. 652–655, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  36. P. B. Panici, S. Basile, F. Maneschi et al., “Systematic pelvic lymphadenectomy vs no lymphadenectomy in early-stage endometrial carcinoma: randomized clinical trial,” Journal of the National Cancer Institute, vol. 100, no. 23, pp. 1707–1716, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  37. C. L. Creutzberg, W. L. J. van Putten, P. C. M. Koper et al., “Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial,” Lancet, vol. 355, no. 9213, pp. 1404–1411, 2000. View at Google Scholar
  38. M. S. Piver, F. Rutledge, and J. P. Smith, “Five classes of extended hysterectomy for women with cervical cancer,” Obstetrics and Gynecology, vol. 44, no. 2, pp. 265–272, 1974. View at Google Scholar
  39. A. Mariani, M. J. Webb, G. L. Keeney, G. Calori, and K. C. Podratz, “Role of wide/radical hysterectomy and pelvic lymph node dissection in endometrial cancer with cervical involvement,” Gynecologic Oncology, vol. 83, no. 1, pp. 72–80, 2001. View at Publisher · View at Google Scholar · View at PubMed
  40. M. P. Boente, “Prognostic factors and long-term survival in endometrial adenocarcinoma with cervical involvement,” Gynecologic Oncology, vol. 51, no. 3, pp. 316–322, 1993. View at Publisher · View at Google Scholar
  41. D. S. Chi, M. Welshinger, E. S. Venkatraman, and R. R. Barakat, “The role of surgical cytoreduction in Stage IV endometrial carcinoma,” Gynecologic Oncology, vol. 67, no. 1, pp. 56–60, 1997. View at Publisher · View at Google Scholar · View at PubMed
  42. R. E. Bristow, M. J. Zerbe, N. B. Rosenshein, F. C. Grumbine, and F. J. Montz, “Stage IVB endometrial carcinoma: the role of cytoreductive surgery and determinants of survival,” Gynecologic Oncology, vol. 78, no. 2, pp. 85–91, 2000. View at Publisher · View at Google Scholar · View at PubMed
  43. H. M. Keys, J. A. Roberts, V. L. Brunetto et al., “A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study,” Gynecologic Oncology, vol. 92, no. 3, pp. 744–751, 2004. View at Publisher · View at Google Scholar · View at PubMed
  44. R. Maggi, A. Lissoni, F. Spina et al., “Adjuvant chemotherapy vs radiotherapy in high-risk endometrial carcinoma: results of a randomised trial,” British Journal of Cancer, vol. 95, no. 3, pp. 266–271, 2006. View at Publisher · View at Google Scholar · View at PubMed
  45. J. E. Bruckman, W. D. Bloomer, A. Marck, R. L. Ehrmann, and R. C. Knapp, “Stage III adenocarcinoma of the endometrium: two prognostic groups,” Gynecologic Oncology, vol. 9, no. 1, pp. 12–17, 1980. View at Google Scholar
  46. J. Tate Thigpen, M. F. Brady, H. D. Homesley et al., “Phase III trial of doxorubicin with or without cisplatin in advanced endometrial carcinoma: a gynecologic oncology group study,” Journal of Clinical Oncology, vol. 22, no. 19, pp. 3902–3908, 2004. View at Publisher · View at Google Scholar · View at PubMed
  47. G. F. Fleming, V. L. Brunetto, D. Cella et al., “Phase III trial of doxorubicin plus cisplatin with or without paclitaxel plus filgrastim in advanced endometrial carcinoma: a gynecologic oncology group study,” Journal of Clinical Oncology, vol. 22, no. 11, pp. 2159–2166, 2004. View at Publisher · View at Google Scholar · View at PubMed
  48. M. E. Randall, V. L. Filiaci, H. Muss et al., “Randomized phase III trial of whole-abdominal irradiation versus doxorubicin and cisplatin chemotherapy in advanced endometrial carcinoma: a gynecologic oncology group study,” Journal of Clinical Oncology, vol. 24, no. 1, pp. 36–44, 2006. View at Publisher · View at Google Scholar · View at PubMed
  49. T. Hogberg, P. Rosenberg, G. Kristensen et al., “A randomised phase III study on adjuvant treatment with radiation (RT) ± chemotherapy (CT) in early stage high-risk endometrial cancer (NSGO-EC-9501/EORTC 55991),” Journal of Clinical Oncology, vol. 25, p. 18S, 2007. View at Google Scholar
  50. National Cancer Institute, “PORTEC-3: Phase III Randomized Study of Concurrent Chemoradiotherapy Followed by Adjuvant Chemotherapy Versus Pelvic Radiotherapy Alone in Patients with High-Risk Stage IB-III Endometrial Carcinoma,” http://www.clinicalresearch.nl/portec3/.
  51. L. Gien, J. Kwon, T. K. Oliver et al., “Adjuvant hormonal therapy for stage I endometrial cancer,” Current Oncology, vol. 15, no. 3, pp. 11–20, 2008. View at Google Scholar