Research Article

Hypermethylation of SOX2 Promoter in Endometrial Carcinogenesis

Table 4

Correlation of SOX2 methylation status with clinicopathological features in endometrial cancers.

Clinicopathological FeaturesPresence of methylated allelesAbsence of methylated allelesP-value
Cases (%)Cases (%)

Histological type
 Endometrioid16 (66.7)32 (84.2).108
 Serous/CCC8 (33.3)6 (15.8)

Grade
 Low (1)7 (29.2)15 (39.5).409
 High (2-3)17 (70.8)22 (60.5)

Stage
 I19 (79.2)32 (84.2).613
 II–IV5 (20.8)6 (15.8)

Myometrial invasion
1/28 (72.7)27 (81.8).517
1/23 (27.3)6 (18.2)

Vascular invasion
 Negative12 (80.0)27 (73.0).596
 Positive3 (20.0)10 (27.0)

Involving cervix
 Negative13 (86.7)34 (91.9).962
 Positive2 (13.3)3 (8.1)

Age
459 (36.0)10 (26.3).413
4516 (64.0)28 (73.7)