Obstetrics and Gynecology International

Review Article

Preclinical Studies of Chemotherapy Using Histone Deacetylase Inhibitors in Endometrial Cancer

Table 2

Data investigating endometrial cancer cell lines treated with different classes of HDACIs.
HDACICell lineED50 (M)
TSAIshikawa5.2 10-8
HEC-1B5.1 × 10-8
HEC597.0 × 10-8
RL95-29.8 ×10-8
KLE7.2 ×10-8
AN3CA1.9 ×10-8
Ark22.5 ×10-8
SAHAIshikawa7.8 × 10-7
HEC-1B7.8 × 10-7
HEC591.2 × 10-6
RL95-22.4 ×10-6
KLE2.5 ×10-6
AN3CA3.1 ×10-6
CBHAIshikawa1.8 × 10-6
HHUA2.5 × 10-6
HEC-1B2.2 × 10-6
ScriptaidIshikawa9.0 × 10-6
NaBIshikawa8.3 × 10-4
HEC-1B8.4 × 10-4
HEC591.8 × 10-3
RL95-23.0 ×10-3
KLE3.9 ×10-3
AN3CA4.1×10-3
VPAIshikawa7.0 × 10-4
HEC-1B7.5 × 10-4
HEC598.2 × 10-4
RL95-22.5 ×10-3
KLE2.3 ×10-3
AN3CA3.8 ×10-3
MS-275Ishikawa9.7 × 10-7
HEC-1B2.2 × 10-6
RL95-21.0 × 10-6
HHUA7.8 ×10-7
AN3CA5.0 × 10-7
Ark25.0 ×10-7
M344Ishikawa 2.3 × 10-6
ApicidineIshikawa1.0 × 10-6
PsAIshikawa7.5 × 10-6
OxamflatinIshikawa2.5 × 10-7
AN3CA2.5 × 10-7
Ark22.5 × 10-7