Obstetrics and Gynecology International / 2010 / Article / Tab 1

Case Report

Obstetrical Complications and Outcome in Two Families with Hereditary Angioedema due to Mutation in the F12 Gene

Table 1

Complement profiles in patients. The diagnosis of patient 1 was reviewed two years after the fourth pregnancy. Complement was quantified for patient 1 at 30 and 34 weeks of gestation (W) and 15 months after the pregnancy (M15) and for patient 2 at 29 weeks and 33 weeks of gestation and 2 months after the pregnancy (M2). Plasma concentrations of C1 inhibitor (C1 inh), C4, and C3 were determined by nephelemetry (Dade Behring). Normal values ranged between 170 and 540 mg/L for C1-inhibitor (C1 Inh), 93 and 380 mg/L for C4, and 660 and 1250 mg/L (±2 SD) for C3. CH50 were determined according to standard procedures. Results are expressed as percent of the CH50 of the reference plasma pool (obtained from one hundred healthy blood donors). C1-inhibitor function (C1 inh fx) was assessed in a chromogenic assay (Technochrom, Biolys, Taluyers, France).

Patient 1Patient 2
Units30 w34 wM1529 w33 wM2

C1 Inh170–540mg/L202186239148161190
C1 inh fx70–130%3325101333584