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Obstetrics and Gynecology International
Volume 2011, Article ID 612817, 6 pages
Clinical Study

Pathways of Metastases from Primary Organs to the Ovaries

1Department of Obstetrics and Gynecology, Otsu Red-Cross Hospital, 1-1-35 Nagara, Otsu, Shiga 520-0046, Japan
2Department of Pathology, Otsu Red-Cross Hospital, 1-1-35 Nagara, Otsu, Shiga 520-0046, Japan

Received 2 February 2011; Revised 7 July 2011; Accepted 11 July 2011

Academic Editor: Peter E. Schwartz

Copyright © 2011 Yukio Yamanishi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


To investigate the metastatic pathways from the primary organs to the ovaries, we examined the microscopic findings from 18 original and 18 metastatic ovarian tumors carefully. In addition, we examined the immunohistochemical findings (Victoria blue stain for vascular invasion and D2-40 expression for lymphangio invasion) of metastatic ovarian tumors carefully. There were 4 (57%) ovarian lymphangio invasion cases in the 7 gastric cancers, but there were no cases in the 6 colorectal cancers (P < 0.05). There were 4 (67%) ovarian vascular invasion cases and one (17%) liver metastasis case in the 6 colorectal cancers, while there were no ovarian vascular invasions (P < 0.05) or no liver metastases in the 7 gastric cancers. The patients with metastatic ovarian tumors originating from distant organs who were treated at the same time as the original cancers had a significantly poorer prognosis than the patients with ovarian tumors treated later (P < 0.05). The rate of lymphatic metastasis from the stomach to the ovary was significantly higher than from the colon to the ovary. In addition we hypothesized that the rate of intravascular metastasis from the colorectum to the ovary was relatively higher than from the stomach to the ovary.