Revised guidelines for offering ovarian cryopreservation to premenarcheal girls with cancer.
The treating team will conduct a detailed discussion of the risks and potential benefits of ovarian cryopreservation with the parents/guardians, and, where age-appropriate, with the patient.
Ovarian cryopreservation will be offered in cases where necessary medical treatments pose a high-risk of ovarian damage (e.g, bone marrow transplantation, whole-abdomen radiationtherapy, and alkylator-intensive chemotherapy).
Ovarian cryopreservation will be offered to girls over 1 years of age. Below 1 year of age, each case should be assessed individually in a multidisciplinary discussion (may be modified with increasing experience).
Ovarian cryopreservation should preferably be performed during a medically indicated anesthetic session (insertion of an indwelling venous catheter, bone marrow biopsy, and autologous bone marrow harvest).
Medical centers providing pediatric oncology care should form multidisciplinary teams to offer this treatment.
