Cardiovascular Risk Factors in Bulgarian Patients with Polycystic Ovary Syndrome and/or Obesity

Table 4

Comparison of hormone levels and the indices of ovarian function between the three groups.

	Group 1		Group 2		Group 3
	Obese		Lean PCOS		Obese PCOS
	n		n		n
Testosterone (nmol/L)	53	2.03±1.22	85	2.42±1.51	67	2.94±1.72^##
Estradiol (pmol/L)	37	0.39±0.34	62	0.45±0.47	40	0.72±1.50
Androstendione (nmol/L)	17	11.58±9.32	48	13.16±9.33	33	13.34±7.53
DHEAS (mcmol/L)	24	7.32±4.29	60	9.24±4.76	54	9.49±4.98
17-OH-progesteron (nmol/L)	16	2.50±1.45	37	3.40±2.93	38	3.49±2.76
LH (U/L)	42	2.91±1.85^∧∧∧	74	5.74±4.01	59	5.17±4.25^##
FSH (U/L)	42	3.33±1.94	76	3.40±2.07	60	3.25±1.81
Prolactin (U/L)	47	355.19±235.88	54	388.45±241.52	49	310.65±184.77
Cortisol 8 : 00 o’clock (nmol/L)	52	405.14±119.38	30	414.67±156.03	41	392.35±134.26
Cortisol 22:00 o’clock (nmol/L)	44	103.35±97.67	15	111.37±39.19	29	138.44±113.19
TSH (U/L)	62	2.09±0.99	39	2.02±1.51	45	1.84±1.17
Presence of polycystic ovaries (PCO) (%)	31	16.1%^∧∧∧	85	84.7%	62	79.0%^###
Right ovary PCO (%)	29	17.2%^∧∧∧	74	87.8%	56	67.9%^###
Left ovary PCO (%)	29	13.8%^∧∧∧	77	74.0%	56	75.0%^###
Right ovary volume (mL)	18	6.99±3.36^∧∧	54	11.75±6.16	37	10.37±5.94
Left ovary volume (mL)	20	4.87±3.06^∧∧	54	9.18±4.46^∗∗∗	35	11.13±6.16
Age of menarche (years)	87	12.73±1.66	86	13.05±1.74	69	12.66±1.62
Length of menstrual cycle (days)	44	29.55±6.01^∧∧∧	56	51.14±23.12^∗	30	40.87±16.86^##
Duration of menstrual bleeding (days)	33	4.88±2.84	44	4.95±1.09	22	6.27±5.55
Rate of menstrual disturbances (%)	107	39.3%^∧∧∧	92	78.3%	79	81.0%^###
Regular menstrual cycle (%)	106	65.1%^∧∧∧	93	23.7%	80	20.0%^###
Oligiomenorrhea (%)	104	28.8%^∧∧∧	93	66.7%	80	66.2%^###
Hypermenorrhea (%)	103	6.8%	91	3.3%	80	7.5%
Polymenorrhea (%)	103	2.9%	92	0%	80	1.2%
Opsomenorrhea (%)	103	3.9%	92	3.3%	80	2.5%
Amenorrhea (%)	103	5.8%	92	10.9%	80	13.8%
Pregnancies	98	0.59±0.77^∧∧∧	87	0.15±0.45	81	0.42±0.78
Births	97	0.51±0.71^∧∧∧	87	0.10±0.34^∗	81	0.31±0.63
Miscarriages	89	0.07±0.36	86	0.05±0.26	78	0.08±0.35
Rate of infertility (%)	40	25.0%^∧	20	55.0%	28	50.0%

^##𝑃<0.01; ^###𝑃<0.001 between group 1 and group 3.
* 𝑃<0.05; **𝑃<0.01; ***𝑃<0.001 between group 2 and group 3.
^∧𝑃<0.05; ^∧∧𝑃<0.01; ^{∧∧ ∧}𝑃<0.001 between group 1 and group 2.
n = number of patients.