Obstetrics and Gynecology International

Clinical Study

An Elevated Maternal Plasma Soluble fms-Like Tyrosine Kinase-1 to Placental Growth Factor Ratio at Midtrimester Is a Useful Predictor for Preeclampsia

Table 6

Sensitivity, specificity, PPV, NPV, PLH ratio, NLH ratio, and accuracy of sFlt-1, PlGF, and sFlt-1/PlGF ratio at the optimum cutoff value for prediction of preeclampsia.
VariablessFlt-1PlGFsFlt-1/PlGF ratio
Sensitivity
(95% CI)		88
78.5–93.8 		85.5
75.7–92 		91.6
82.9–96.3
Specificity
(95% CI)		83.6
78.3–87.8 		77.2
71.4–82.1 		86.4
81.4–90.3
PPV
(95% CI)		64
54.5–72.7 		55.5
46.4–64.2 		69.1
59.5–77.4
NPV
(95% CI)		95.4
91.5–97.7 		94.1
89.8–96.8 		96.9
93.4–98.6
PLH ratio
(95% CI)		5.4
4–7.2 		3.8
2.9–4.8 		6.7
4.9–9.3
NLH ratio
(95% CI)		0.14
0.08–0.26 		0.19
0.11–0.32 		0.1
0.05–0.2
Accuracy (%)84.779.387.7
sFlt-1: soluble fms-like tyrosine kinase 1; PlGF: placental growth factor; CI: confidence interval; PPV: positive predictive value; NPV: negative predictive value; PLH: positive likelihood ratio; NLH: negative likelihood ratio.