The Natural History of Uterine Leiomyomas: Morphometric Concordance with Concepts of Interstitial Ischemia and Inanosis
Phase 4 Fibroid. Hyalinized areas of fibroids, as in this phase 4 tumor, sometimes exhibit prominently reduced vascularity, in comparison to the adjacent areas of residual smooth muscle. Factor 8 immunostaining highlights the widely separated vessels in (a), and the distance between these vessels, measured with an ocular micrometer, is shown in (b). Note that the distances between adjacent vessels range from 110 μm to 360 μm, often exceeding the physiologic limits of cell survival, as evidenced by almost a total absence of cellularity within the intervening stroma. 10x original objective magnification.