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Obstetrics and Gynecology International
Volume 2013 (2013), Article ID 368543, 7 pages
Obesity and the Endometrium: Adipocyte-Secreted Proinflammatory TNFα Cytokine Enhances the Proliferation of Human Endometrial Glandular Cells
1Department of Obstetrics and Gynecology, Center for Women’s Health Research, Meharry Medical College, Nashville, TN 37208, USA
2Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
Received 30 May 2013; Accepted 22 September 2013
Academic Editor: Eric Prossnitz
Copyright © 2013 Sangeeta Nair et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- E. M. Buchanan, L. C. Weinstein, and C. Hillson, “Endometrial cancer,” American Family Physician, vol. 80, no. 10, pp. 1075–1088, 2009.
- U.S. Cancer Statistics Working Group, United States Cancer Statistics: 1999–2009 Incidence and Mortality Web-Based Report, Department of Health and Human Services, Centers for Disease Control and Prevention, and National Cancer Institute, Atlanta, Ga, USA, 2013, http://apps.nccd.cdc.gov/uscs/.
- J. E. Allard and G. L. Maxwell, “Race disparities between black and white women in the incidence, treatment, and prognosis of endometrial cancer,” Cancer Control, vol. 16, no. 1, pp. 53–56, 2009.
- R. Kaaks, A. Lukanova, and M. S. Kurzer, “Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review,” Cancer Epidemiology Biomarkers and Prevention, vol. 11, no. 12, pp. 1531–1543, 2002.
- E. E. Calle and R. Kaaks, “Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms,” Nature Reviews Cancer, vol. 4, no. 8, pp. 579–591, 2004.
- F. Modugno, R. B. Ness, C. Chen, and N. S. Weiss, “Inflammation and endometrial cancer: a hypothesis,” Cancer Epidemiology Biomarkers and Prevention, vol. 14, no. 12, pp. 2840–2847, 2005.
- L. J. Schouten, R. A. Goldbohm, and P. A. van den Brandt, “Anthropometry, physical activity, and endometrial cancer risk: results from the Netherlands cohort study,” International Journal of Gynecological Cancer, vol. 16, supplement 2, p. 492, 2006.
- T. Bjørge, A. Engeland, S. Tretli, and E. Weiderpass, “Body size in relation to cancer of the uterine corpus in 1 million Norwegian women,” International Journal of Cancer, vol. 120, no. 2, pp. 378–383, 2007.
- G. S. Hotamisligil, N. S. Shargill, and B. M. Spiegelman, “Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance,” Science, vol. 259, no. 5091, pp. 87–91, 1993.
- F. Samad, K. Yamamoto, M. Pandey, and D. J. Loskutoff, “Elevated expression of transforming growth factor-β in adipose tissue from obese mice,” Molecular Medicine, vol. 3, no. 1, pp. 37–48, 1997.
- S. K. Fried, D. A. Bunkin, and A. S. Greenberg, “Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid,” The Journal of Clinical Endocrinology and Metabolism, vol. 83, no. 3, pp. 847–850, 1998.
- P. Sartipy and D. J. Loskutoff, “Monocyte chemoattractant protein 1 in obesity and insulin resistance,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 12, pp. 7265–7270, 2003.
- U. N. Das, “Is obesity an inflammatory condition?” Nutrition, vol. 17, no. 11-12, pp. 953–966, 2001.
- A. Festa, R. D'Agostino Jr., K. Williams et al., “The relation of body fat mass and distribution to markers of chronic inflammation,” International Journal of Obesity, vol. 25, no. 10, pp. 1407–1415, 2001.
- H. Inadera, “The usefulness of circulating adipokine levels for the assessment of obesity-related health problems,” International Journal of Medical Sciences, vol. 5, no. 5, pp. 248–262, 2008.
- T. Kondo, I. Kobayashi, and M. Murakami, “Effect of exercise on circulating adipokine levels in obese young women,” Endocrine Journal, vol. 53, no. 2, pp. 189–195, 2006.
- P. Dandona, R. Weinstock, K. Thusu, E. Abdel-Rahman, A. Aljada, and T. Wadden, “Tumor necrosis factor-α in sera of obese patients: fall with weight loss,” The Journal of Clinical Endocrinology and Metabolism, vol. 83, no. 8, pp. 2907–2910, 1998.
- E. E. Kershaw and J. S. Flier, “Adipose tissue as an endocrine organ,” The Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 6, pp. 2548–2556, 2004.
- B. B. Aggarwal, “Tumor necrosis factors: developments during the last decade,” European Cytokine Network, vol. 7, no. 2, pp. 93–124, 1996.
- S. I. Grivennikov and M. Karin, “Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage,” Annals of the Rheumatic Diseases, vol. 70, no. 1, pp. 104–108, 2011.
- M. Philip, D. A. Rowley, and H. Schreiber, “Inflammation as a tumor promoter in cancer induction,” Seminars in Cancer Biology, vol. 14, no. 6, pp. 433–439, 2004.
- L. M. Coussens and Z. Werb, “Inflammation and cancer,” Nature, vol. 420, no. 6917, pp. 860–867, 2002.
- A. McTiernan, M. Irwin, and V. Vongruenigen, “Weight, physical activity, diet, and prognosis in breast and gynecologic cancers,” Journal of Clinical Oncology, vol. 28, no. 26, pp. 4074–4080, 2010.
- S. Tabibzadeh, P. G. Satyaswaroop, M. von Wolff, and T. Strowitzki, “Regulation of TNF-α mRNA expression in endometrial cells by TNF-α and by oestrogen withdrawal,” Molecular Human Reproduction, vol. 5, no. 12, pp. 1141–1149, 1999.
- L. A. Salamonsen, J. Zhang, and M. Brasted, “Leukocyte networks and human endometrial remodelling,” Journal of Reproductive Immunology, vol. 57, no. 1-2, pp. 95–108, 2002.
- R. Romero, J. Espinoza, and M. Mazor, “Can endometrial infection/inflammation explain implantation failure, spontaneous abortion, and preterm birth after in vitro fertilization?” Fertility and Sterility, vol. 82, no. 4, pp. 799–804, 2004.
- L. Dossus, S. Becker, S. Rinaldi et al., “Tumor necrosis factor (TNF)-α, soluble TNF receptors and endometrial cancer risk: the EPIC study,” International Journal of Cancer, vol. 129, no. 8, pp. 2032–2037, 2011.
- S. Nair and A. Al-Hendy, “Adipocytes enhance the proliferation of human leiomyoma cells via TNF-α proinflammatory cytokine,” Reproductive Sciences, vol. 18, no. 12, pp. 1186–1192, 2011.
- P. Trayhurn and I. S. Wood, “Adipokines: inflammation and the pleiotropic role of white adipose tissue,” British Journal of Nutrition, vol. 92, no. 3, pp. 347–355, 2004.
- B. Wang and P. Trayhurn, “Acute and prolonged effects of TNF-α on the expression and secretion of inflammation-related adipokines by human adipocytes differentiated in culture,” Pflügers Archiv—European Journal of Physiology, vol. 452, no. 4, pp. 418–427, 2006.
- S. Hosono, K. Matsuo, K. Hirose et al., “Weight gain during adulthood and body weight at age 20 are associated with the risk of endometrial cancer in Japanese women,” Journal of Epidemiology, vol. 21, no. 6, pp. 466–473, 2011.
- V. L. Stevens, E. J. Jacobs, J. Sun et al., “Weight cycling and risk of endometrial cancer,” Cancer Epidemiology Biomarkers and Prevention, vol. 21, no. 5, pp. 747–752, 2012.
- F. Farinati, R. Cardin, M. Cassaro et al., “Helicobacter pylori, inflammation, oxidative damage and gastric cancer: a morphological, biological and molecular pathway,” European Journal of Cancer Prevention, vol. 17, no. 3, pp. 195–200, 2008.
- M. W. Rajala and P. E. Scherer, “Minireview: the adipocyte—at the crossroads of energy homeostasis, inflammation, and atherosclerosis,” Endocrinology, vol. 144, no. 9, pp. 3765–3773, 2003.
- U. Gaur and B. B. Aggarwal, “Regulation of proliferation, survival and apoptosis by members of the TNF superfamily,” Biochemical Pharmacology, vol. 66, no. 8, pp. 1403–1408, 2003.
- B. Saile, N. Matthes, H. El Armouche, K. Neubauer, and G. Ramadori, “The bcl, NFΚB and p53/p21WAF1 systems are involved in spontaneous apoptosis and in the anti-apoptotic effect of TGF-β or TNF-α on activated hepatic stellate cells,” European Journal of Cell Biology, vol. 80, no. 8, pp. 554–561, 2001.
- C. Tsigos, I. Kyrou, E. Chala et al., “Circulating tumor necrosis factor alpha concentrations are higher in abdominal versus peripheral obesity,” Metabolism, vol. 48, no. 10, pp. 1332–1335, 1999.
- R. Marfella, K. Esposito, M. Siniscalchi et al., “Effect of weight loss on cardiac synchronization and proinflammatory cytokines in premenopausal obese women,” Diabetes Care, vol. 27, no. 1, pp. 47–52, 2004.
- B. B. Aggarwal, “Signalling pathways of the TNF superfamily: a double-edged sword,” Nature Reviews Immunology, vol. 3, no. 9, pp. 745–756, 2003.
- V. Baud and M. Karin, “Signal transduction by tumor necrosis factor and its relatives,” Trends in Cell Biology, vol. 11, no. 9, pp. 372–377, 2001.
- S. J. Mathew, D. Haubert, M. Krönke, and M. Leptin, “Looking beyond death: a morphogenetic role for the TNF signalling pathway,” Journal of Cell Science, vol. 122, no. 12, pp. 1939–1946, 2009.
- H. Wajant, K. Pfizenmaier, and P. Scheurich, “Tumor necrosis factor signaling,” Cell Death and Differentiation, vol. 10, no. 1, pp. 45–65, 2003.
- S. A. Salama, M. W. Kamel, C. R. Diaz-Arrastia et al., “Effect of tumor necrosis factor-α on estrogen metabolism and endometrial cells: potential physiological and pathological relevance,” The Journal of Clinical Endocrinology and Metabolism, vol. 94, no. 1, pp. 285–293, 2009.