G Protein-Coupled Estrogen Receptor-Selective Ligands Modulate Endometrial Tumor Growth
GPER mediates PI3K activation in Hec50 cells. (a) Hec50 cells were transfected with no siRNA (mock transfected), control siRNA or siRNA targeting GPER (GPER siRNA), and the PH-RFP reporter. Transfected Hec50 cells were stimulated with vehicle, estrogen (10 nM E2), or G-1 (10 nM). (b) Hec50 cells transfected with no siRNA (mock transfected) and control siRNA or siRNA targeting GPER (GPER siRNA) were stained for GPER (with carboxy-terminal antibody) to demonstrate the specific knockdown of GPER in the GPER siRNA-treated cells.
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.